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Design and synthesis of some furan derivatives and Its lsosteres of anticipated antitumor activity / Shaimaa Mohamed Abdelrahman ; Supervised Samir M. Elmoghazy , Nahed M. Eid , Sahar M. AbouSeri

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Shaimaa Mohamed Abdelrahman , 2014Description: 136 P. : charts , photographs ; 25cmOther title:
  • تصميم و تشييد بعض مشتقات الفيوران و متشابهاتها من المتوقع أن يكون لها فاعلية ضد الأورام [Added title page title]
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Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutical Chemistry Summary: In this thesis, novel series of colchicine binding site inhibitors (CBSIs) were designed. Molecular modeling techniques were used to support the design. Chalcones derivatives IIa - d, cyclohexenone derivatives IIIa,b, IVa,b, cyanopyridine derivatives VIa, b, isoxazoline derivatives VIIa - d, pyrazoline derivatives VIIIa, b, IXa, b, Xa - f, XIa, b and XIIa - f were synthesized. Eight target compounds were evaluated for antitumor activity at National cancer institute, NCI, maryland, USA against several cell lines. Twenty four target compounds were evaluated for antitumor activity and their ability to inhibit tubulin polymerization against leukemia SR cell line at Vacsera, Egypt
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.05.Ph.D.2014.Sh.D (Browse shelf(Opens below)) Not for loan 01010110066185000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.05.Ph.D.2014.Sh.D (Browse shelf(Opens below)) 66185.CD Not for loan 01020110066185000

Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutical Chemistry

In this thesis, novel series of colchicine binding site inhibitors (CBSIs) were designed. Molecular modeling techniques were used to support the design. Chalcones derivatives IIa - d, cyclohexenone derivatives IIIa,b, IVa,b, cyanopyridine derivatives VIa, b, isoxazoline derivatives VIIa - d, pyrazoline derivatives VIIIa, b, IXa, b, Xa - f, XIa, b and XIIa - f were synthesized. Eight target compounds were evaluated for antitumor activity at National cancer institute, NCI, maryland, USA against several cell lines. Twenty four target compounds were evaluated for antitumor activity and their ability to inhibit tubulin polymerization against leukemia SR cell line at Vacsera, Egypt

Issued also as CD

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