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Pharmacological study on the combined effect of tamoxifen and 3 - bromopyruvate on breast cancer / Yasmin Mostafa Attia ; Supervised Hanan S. Elabhar , Mahmoud M. Elmerzabani , Samia A. Shouman

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Yasmin Mostafa Attia , 2014Description: 145 P. : charts , photographs ; 25cmOther title:
  • الدراسة الدوائية للتأثير المشترك للتاموكسيفين و3- بروموبيروفات على سرطان الثدى [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology Summary: Cancer is a disease of complex etiology and its treatment requires combinations of drugs which can act simultaneously on different targets. Therefore, development of multi - functional and multi-targeting chemotherapeutic agents is an alternative to drug combination protocols. Tamoxifen, (TAM) a selective estrogen receptor modulator, is widely used for treatment and prevention of breast cancer. 3-Bromopyruvate (3 - BP) is a glycolytic inhibitor with impressive antitumor effects on several models of animal tumors and cell lines. The aim of the present study was to investigate the combined antitumor effect of TAM and 3-BP in vitro using MCF-7 and T47D cell lines and in vivo using ehrlich ascites carcinoma. In addition, the current study aimed at exploring the type and mechanism of their interaction via assessment of apoptosis, angiogenesis and metastatic markers
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.09.M.Sc.2014.Ya.P (Browse shelf(Opens below)) Not for loan 01010110066187000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.09.M.Sc.2014.Ya.P (Browse shelf(Opens below)) 66187.CD Not for loan 01020110066187000

Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology

Cancer is a disease of complex etiology and its treatment requires combinations of drugs which can act simultaneously on different targets. Therefore, development of multi - functional and multi-targeting chemotherapeutic agents is an alternative to drug combination protocols. Tamoxifen, (TAM) a selective estrogen receptor modulator, is widely used for treatment and prevention of breast cancer. 3-Bromopyruvate (3 - BP) is a glycolytic inhibitor with impressive antitumor effects on several models of animal tumors and cell lines. The aim of the present study was to investigate the combined antitumor effect of TAM and 3-BP in vitro using MCF-7 and T47D cell lines and in vivo using ehrlich ascites carcinoma. In addition, the current study aimed at exploring the type and mechanism of their interaction via assessment of apoptosis, angiogenesis and metastatic markers

Issued also as CD

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