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Value of serum and biliary neutrophil gelatinase - associated lipocalin (NGAL) as a diagnostic marker for cholangiocarcinoma / Ahmed Abdelaaty Mohammed ; Supervised Eman Medhat Hassan , Mohammed Salah Abdelbary , Hanan Hassan Fouad

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Ahmed Abdelaaty Mohammed , 2014Description: 164 P. : facsimiles ; 25cmOther title:
  • دور الليبوكـالين المقترن بجيــلاتيناز النيوتروفيــل فى الـدم و السائل المرارى فى تشخيص سرطان القنوات المرارية [Added title page title]
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  • Issued also as CD
Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Tropical Medicine Summary: Cholangiocarcinoma (CCA) is the most frequent biliary malignancy. It is difficult to diagnose owing to its anatomic location, growth patterns and lack of definite diagnostic criteria. Neutrophil gelatinase - associated lipocalin (NGAL), is a glycoprotein, which is found to increase in many cancers including (CCA). Measurement of NGAL in bile and serum of patients with extrahepatic biliary strictures and its evaluation as a diagnostic marker in differentiating the malignant from the benign strictures, as compared to brush cytology and to other known markers CA19-9 and CEA and its correlation with laboratory variables and the stage of the disease. The study is a cross sectional study including 60 patients presented to endoscopic retrograde cholangiopancreatography (ERCP) unit with extrahepatic biliary obstruction for diagnosis and drainage. Brush cytology was taken from the site of stricture, bile and serum samples were collected for measurement of NGAL, according to the results of brush cytology, Patients were grouped as follows: Group A including 29 patients with malignant extrahepatic strictures, Group B 27 patients with benign extrahepatic strictures as 4 patients were excluded due to unsatisfactory cytology sample
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.33.Ph.D.2014.Ah.V (Browse shelf(Opens below)) Not for loan 01010110066254000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.33.Ph.D.2014.Ah.V (Browse shelf(Opens below)) 66254.CD Not for loan 01020110066254000
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Cai01.11.33.Ph.D.2013.Sh.R Repeated autobgous infusion of haematopoietic stem cells in patients with liver insufficiency / Cai01.11.33.Ph.D.2014.Ah.S Single nucleotide polymorphism (SNP) rs8099917 as a predictive factor of virological response to pegylated interferon plus ribavirin in treatment of chronic hepatitis C virus patients / Cai01.11.33.Ph.D.2014.Ah.S Single nucleotide polymorphism (SNP) rs8099917 as a predictive factor of virological response to pegylated interferon plus ribavirin in treatment of chronic hepatitis C virus patients / Cai01.11.33.Ph.D.2014.Ah.V Value of serum and biliary neutrophil gelatinase - associated lipocalin (NGAL) as a diagnostic marker for cholangiocarcinoma / Cai01.11.33.Ph.D.2014.Ah.V Value of serum and biliary neutrophil gelatinase - associated lipocalin (NGAL) as a diagnostic marker for cholangiocarcinoma / Cai01.11.33.Ph.D.2014.Ba.H Histopathological findings in liver biopsy in relation to virological response in chronic hepatitis C patients Receiving combined therapy / Cai01.11.33.Ph.D.2014.Ba.H Histopathological findings in liver biopsy in relation to virological response in chronic hepatitis C patients Receiving combined therapy /

Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Tropical Medicine

Cholangiocarcinoma (CCA) is the most frequent biliary malignancy. It is difficult to diagnose owing to its anatomic location, growth patterns and lack of definite diagnostic criteria. Neutrophil gelatinase - associated lipocalin (NGAL), is a glycoprotein, which is found to increase in many cancers including (CCA). Measurement of NGAL in bile and serum of patients with extrahepatic biliary strictures and its evaluation as a diagnostic marker in differentiating the malignant from the benign strictures, as compared to brush cytology and to other known markers CA19-9 and CEA and its correlation with laboratory variables and the stage of the disease. The study is a cross sectional study including 60 patients presented to endoscopic retrograde cholangiopancreatography (ERCP) unit with extrahepatic biliary obstruction for diagnosis and drainage. Brush cytology was taken from the site of stricture, bile and serum samples were collected for measurement of NGAL, according to the results of brush cytology, Patients were grouped as follows: Group A including 29 patients with malignant extrahepatic strictures, Group B 27 patients with benign extrahepatic strictures as 4 patients were excluded due to unsatisfactory cytology sample

Issued also as CD

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