Role of GSTP1 and RAD51 gene polymorphisms in the pathogenesis of acute myeloid leukemia / Eman Mahmoud Soliman Mohamed ; Supervised Khaled Mostafa AboulEnein , Amany Mohamed Helal , Gamal Thabet Ali Ebid

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Eman Mahmoud Soliman Mohamed

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TextLanguage: English Publication details: Cairo : Eman Mahmoud Soliman Mohamed , 2015Description: 160 P. : facsimiles ; 25cmOther title:

دور التنوع الجينى للجى اس تى بى ١و الراد ٥١ فى سرطان الدم الميلودى الحاد [Added title page title]

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Dissertation note: Thesis (Ph.D.) - Cairo University - National Cancer Institute - Department of Clinical Pathology Summary: Acute myeloid leukemia (AML) is a clonal disorder charachterized by acquisition of somatic mutations in hematopoietic progenitors with accumulation of leukemic cells in the bone marrow replacing most of the normal hematopoietic cells. Several reports have highlighted the association of the polymorphisms of genes such as genes involved in detoxification of carcinogens like GSTP1 and DNA repair genes like RAD51 with specific cancers including AML. The causes of the majority of acute leukemias are unknown and likely to involve an interaction between genetic and environmental factors. Unfavorable genetic environmental interactions might be involved in the genesis of AML

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Item type	Current library	Home library	Call number	Copy number	Status	Barcode
Thesis	قاعة الرسائل الجامعية - الدور الاول	المكتبة المركزبة الجديدة - جامعة القاهرة	Cai01.19.03.Ph.D.2015.Em.R (Browse shelf(Opens below))		Not for loan	01010110066257000
CD - Rom	مخـــزن الرســائل الجـــامعية - البدروم	المكتبة المركزبة الجديدة - جامعة القاهرة	Cai01.19.03.Ph.D.2015.Em.R (Browse shelf(Opens below))	66257.CD	Not for loan	01020110066257000

Thesis (Ph.D.) - Cairo University - National Cancer Institute - Department of Clinical Pathology

Acute myeloid leukemia (AML) is a clonal disorder charachterized by acquisition of somatic mutations in hematopoietic progenitors with accumulation of leukemic cells in the bone marrow replacing most of the normal hematopoietic cells. Several reports have highlighted the association of the polymorphisms of genes such as genes involved in detoxification of carcinogens like GSTP1 and DNA repair genes like RAD51 with specific cancers including AML. The causes of the majority of acute leukemias are unknown and likely to involve an interaction between genetic and environmental factors. Unfavorable genetic environmental interactions might be involved in the genesis of AML

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