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Genotoxic and anti-genotoxic studies of both a novel anti-schistosomal drug and praziquantel in mice infected with Schistosoma mansoni / Aliaa Ragheb Mohammed Ibrahim ; Supervised Magda Mohamed Noshy , Amal Elshennawy

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Aliaa Ragheb Mohammed Ibrahim , 2015Description: 174 P. : charts , facsimiles , maps ; 25cmOther title:
  • دراسات على السمية الوراثية ومقاومتها لكلا من عقار جديد مضاد للبلهارسيا وعقار البرازيكوانتيل فى الفئران المصابة بالشيشتوسوما مانسوناى [Added title page title]
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Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Science - Department of Zoology Summary: Chemotherapy with praziquantel (PZQ) is the cornerstone of schistosomiasis control. However, its extensive use in multiple reinfections and in non-infected individuals for prevention caused increase in parasite tolerance and/or resistance against this drug. Therefore, various studies have sought to identify new safe and effective drugs as alternatives to PZQ or in conjunction with PZQ to combat the growing threat of drug-resistant parasites. The novel enaminone derivative 4-hydroxyquinolin, (BDHQ), is an experimentally promising antischistosomal agent that has been proven to exhibit in vivo schistosomicidal effect and it has a lower toxicity than PZQ. Several studies reported that infection with Schistosoma mansoni causes an increase in oxidative stress as consequence of reactive oxygen species (ROS) generation. These ROS potentiate membranes lipid peroxidation and oxidative DNA damage
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.12.21.Ph.D.2015.Al.G (Browse shelf(Opens below)) Not for loan 01010110066223000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.12.21.Ph.D.2015.Al.G (Browse shelf(Opens below)) 66223.CD Not for loan 01020110066223000

Thesis (Ph.D.) - Cairo University - Faculty of Science - Department of Zoology

Chemotherapy with praziquantel (PZQ) is the cornerstone of schistosomiasis control. However, its extensive use in multiple reinfections and in non-infected individuals for prevention caused increase in parasite tolerance and/or resistance against this drug. Therefore, various studies have sought to identify new safe and effective drugs as alternatives to PZQ or in conjunction with PZQ to combat the growing threat of drug-resistant parasites. The novel enaminone derivative 4-hydroxyquinolin, (BDHQ), is an experimentally promising antischistosomal agent that has been proven to exhibit in vivo schistosomicidal effect and it has a lower toxicity than PZQ. Several studies reported that infection with Schistosoma mansoni causes an increase in oxidative stress as consequence of reactive oxygen species (ROS) generation. These ROS potentiate membranes lipid peroxidation and oxidative DNA damage

Issued also as CD

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