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Pathological and biochemical studies on the protective role of some antioxidants against the toxic and carcinogenic effects of hexavalent chromium in albino rats / Merhan Essam Ali ; Supervised Mohamed Osama Abdelaal Elshazly , Sahar Samir Mahmoud , Ashraf Mohammed H. Morgan

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Merhan Essam Ali , 2015Description: 209 P. : facsimiles ; 25cmOther title:
  • دراسات باثولوجيه و بيوكيميائيه على الدور الوقائى لبعض مضادات الأكسده ضد التأثيرات السامه و المسرطنه للكروميوم السداسى فى الجرذان البيضاء [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Veterinary Medicine - Department of Clinical Pathology Summary: The wide environmental distribution of Cr leads to an increased interest of its toxicity and biological effects. This study was conducted to investigate the possible protective effect of Spirulina platensis and/or radish oil against chromium - induced toxicity and carcinogenecity. Eighty four adult male albino rats were divided into 7 equal groups (Gps). Gp1 served as a control, Gps 2 , 3 and 4 exposed to Spirulina platensis (300 mg / kg b.wt per os), radish oil (0.07 ml / kg b.wt per os) and sodium dichromate dihydrate (SDD) (via drinking water at concentration of 520 mg / l), respectively, for 3 months. While, Gp5, 6, 7 rats exposed to SDD concomitantly with Spirulina, radish oil, both respectively with the same previously mentioned doses, routes and duration of exposure. Chromium administration caused significant alterations in the hematological parameters, serum iron and AFP as well as hepatic and renal function markers that was objectified by significantly increased alanine transaminase (ALT), alkaline phosphatase (ALP), urea and creatinine levels accompanied with significantly increased MDA level, decreased catalase activity as well as glutathion content in blood and hepatic tissue homogenates
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.10.05.M.Sc.2015.Me.P (Browse shelf(Opens below)) Not for loan 01010110066273000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.10.05.M.Sc.2015.Me.P (Browse shelf(Opens below)) 66273.CD Not for loan 01020110066273000

Thesis (M.Sc.) - Cairo University - Faculty of Veterinary Medicine - Department of Clinical Pathology

The wide environmental distribution of Cr leads to an increased interest of its toxicity and biological effects. This study was conducted to investigate the possible protective effect of Spirulina platensis and/or radish oil against chromium - induced toxicity and carcinogenecity. Eighty four adult male albino rats were divided into 7 equal groups (Gps). Gp1 served as a control, Gps 2 , 3 and 4 exposed to Spirulina platensis (300 mg / kg b.wt per os), radish oil (0.07 ml / kg b.wt per os) and sodium dichromate dihydrate (SDD) (via drinking water at concentration of 520 mg / l), respectively, for 3 months. While, Gp5, 6, 7 rats exposed to SDD concomitantly with Spirulina, radish oil, both respectively with the same previously mentioned doses, routes and duration of exposure. Chromium administration caused significant alterations in the hematological parameters, serum iron and AFP as well as hepatic and renal function markers that was objectified by significantly increased alanine transaminase (ALT), alkaline phosphatase (ALP), urea and creatinine levels accompanied with significantly increased MDA level, decreased catalase activity as well as glutathion content in blood and hepatic tissue homogenates

Issued also as CD

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