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Biochemical assay of respiratory chain enzymes among Egyptian pediatric patients with mitochondrial diseases / Doaa Mohamed Abdo Mostafa ; Supervised Fayza Abdelhamid Hassan ,Laila Abdelmotleb Sleim , Rudy Van Coster

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Doaa Mohamed Abdo Mostafa , 2015Description: 147 P. : charts ; 25cmOther title:
  • القياس الكيميائى لسلسلة انزيمات التنفس في الاطفال المصريين المصابين بامراض الميتوكوندريا [Added title page title]
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Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology Summary: Background: Mitochondrial dysfunction is one of the most common causes of pediatric Encephalomyopathies. Mitochondrial respiratory chain enzymes deficiency is an important cause of mitochondrial dysfunction. Objectives: This study aimed at assessment of the prevalence of respiratory chain enzymes deficiency among 23 Egyptian children diagnosed as mitochondrial Encephalomyopathies. Also, to highlight the role of biochemical assay of those enzymes to reach the proper diagnosis in these disorders. Subjects and methods: Open muscle biopsy was conducted in 23 patients. Biochemical analysis of the activities of the respiratory chain enzymes was determined in the muscle biopsy homogenate along with the Citrate Synthase enzyme and total protein in the prepared muscle homogenate using standard spectrophotometric techniques
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.07.Ph.D.2015.Do.B (Browse shelf(Opens below)) Not for loan 01010110066406000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.07.Ph.D.2015.Do.B (Browse shelf(Opens below)) 66406.CD Not for loan 01020110066406000

Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology

Background: Mitochondrial dysfunction is one of the most common causes of pediatric Encephalomyopathies. Mitochondrial respiratory chain enzymes deficiency is an important cause of mitochondrial dysfunction. Objectives: This study aimed at assessment of the prevalence of respiratory chain enzymes deficiency among 23 Egyptian children diagnosed as mitochondrial Encephalomyopathies. Also, to highlight the role of biochemical assay of those enzymes to reach the proper diagnosis in these disorders. Subjects and methods: Open muscle biopsy was conducted in 23 patients. Biochemical analysis of the activities of the respiratory chain enzymes was determined in the muscle biopsy homogenate along with the Citrate Synthase enzyme and total protein in the prepared muscle homogenate using standard spectrophotometric techniques

Issued also as CD

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