header
Local cover image
Local cover image
Image from OpenLibrary

Taq1 B polymorphism of cholestryl ester transfer protein ; a potential risk factor for atherosclerosis in type 2 diabetes mellitus / Fatma Elzahraa Abdelmoneim Elshafie , Supervised Hazem Elsayed Abou Youssef , Marianne Fathy Ishak Morgan , Randa Fayez Abdelsalam

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Fatma Elzahraa Abdelmoneim Elshafie , 2015Description: 119 P. : charts , facsimiles ; 25cmOther title:
  • من البروتين الناقل للكوليسترول استر كعامل خطر محتمل لتصلب الشرايين في داء السكري من النوع الثاني( Taq)1B تعدد أشكال [Added title page title]
Subject(s): Online resources: Available additional physical forms:
  • Issued also as CD
Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology Summary: Vascular complications are the main cause of morbidity and mortality in type 2 diabetic patients. Genetic susceptibility is associated with the evolution of diabetic complications. Cholesteryl ester transfer protein (CETP) plays a major role in cholesterol metabolism, and polymorphisms within its gene may underlie the susceptibility to atherosclerosis. Taq1B polymorphism (SNP:rs708272,c.118+ G277A) is the most widely studied one results from G to A base pair change at nucleotide 277 in intron 1 of the CETP gene which is located on chromosome 16q21. This polymorphism disrupts Taq1 restriction site. The allele containing the Taq1 endonuclease site is called B1, while the allele without the restriction site is called B2. The less common B2 allele has been associated with increased HDL-C levels and decreased CETP activity and levels. The B1 allele of CETP increased the risk of coronary heart disease (CHD) and type 2 diabetes mellitus (T2DM) 1.65- and 1.7-fold, respectively. The present study aims to elucidate the association between (SNP:rs708272,c.118+ G277A) and the prevalence of vascular complications in T2DM.
Tags from this library: No tags from this library for this title. Log in to add tags.
Star ratings
    Average rating: 0.0 (0 votes)
Holdings
Item type Current library Home library Call number Copy number Status Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.07.M.Sc.2015.Fa.T (Browse shelf(Opens below)) Not for loan 01010110066476000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.07.M.Sc.2015.Fa.T (Browse shelf(Opens below)) 66476.CD Not for loan 01020110066476000

Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology

Vascular complications are the main cause of morbidity and mortality in type 2 diabetic patients. Genetic susceptibility is associated with the evolution of diabetic complications. Cholesteryl ester transfer protein (CETP) plays a major role in cholesterol metabolism, and polymorphisms within its gene may underlie the susceptibility to atherosclerosis. Taq1B polymorphism (SNP:rs708272,c.118+ G277A) is the most widely studied one results from G to A base pair change at nucleotide 277 in intron 1 of the CETP gene which is located on chromosome 16q21. This polymorphism disrupts Taq1 restriction site. The allele containing the Taq1 endonuclease site is called B1, while the allele without the restriction site is called B2. The less common B2 allele has been associated with increased HDL-C levels and decreased CETP activity and levels. The B1 allele of CETP increased the risk of coronary heart disease (CHD) and type 2 diabetes mellitus (T2DM) 1.65- and 1.7-fold, respectively. The present study aims to elucidate the association between (SNP:rs708272,c.118+ G277A) and the prevalence of vascular complications in T2DM.

Issued also as CD

There are no comments on this title.

to post a comment.

Click on an image to view it in the image viewer

Local cover image