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Synthesis and biological activity of some novel heterocyclic compounds / Mahmoud Nabil Mahmoud Yousif ; Supervised Makarem Mohamed Said , Farouk Mohammed Ezat Abdelmegeid

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Mahmoud Nabil Mahmoud Yousif , 2015Description: 121 P. : charts ; 25cmOther title:
  • تحضير والفاعلية البيولوجية لبعض المركبات الجديدة غير متجانسة الحلقة [Added title page title]
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  • Issued also as CD
Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Organic Chemistry Summary: Reaction of 2,2,6,6-tetramethylpiperidin-4-one (1) with different aromatic aldehydes afforded the diarylidenes 2a-f. Compound 1 reacted in one-pot reaction with aromatic aldehydes and malononitrile in ammonium acetate, and also with arylidene malononitrile in ammonium acetate to give the corresponding 1,6-naphthyridine-3-carbonitriles 3a-f and 4a-f, respectively. Compounds 3b, 4b were acetylated using acetic anhydride to give the mono- and tri- acetylated products 5a,b; 6a,b, respectively. Compound 1 was reacted with cyanoacetamide and aromatic aldehydes in ammonium acetate or ethyl cyanoactate and aromatic aldehydes in ammonium acetate to give 1,6-naphthyridine- 3-carboxamides 7a-c or 1,6-naphthyridine-3-carboxylates 8a-c, respectively. On the other hand, reaction of compound 1 with aromatic aldehydes and malononitrile in triethylamine afforded the pyrano[3,2-c]pyridine-3- carbonitriles 9a-c. Also, compound 9c was acetylated with acetic anhydride to give the tri-acetylated product 10. Pyrido[4,3-d]pyrimidine-2-thione derivatives 11a-c were obtained by reaction of compound 1 with aromatic aldehydes and thiourea
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.04.Ph.D.2015.Ma.S (Browse shelf(Opens below)) Not for loan 01010110066423000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.04.Ph.D.2015.Ma.S (Browse shelf(Opens below)) 66423.CD Not for loan 01020110066423000

Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Organic Chemistry

Reaction of 2,2,6,6-tetramethylpiperidin-4-one (1) with different aromatic aldehydes afforded the diarylidenes 2a-f. Compound 1 reacted in one-pot reaction with aromatic aldehydes and malononitrile in ammonium acetate, and also with arylidene malononitrile in ammonium acetate to give the corresponding 1,6-naphthyridine-3-carbonitriles 3a-f and 4a-f, respectively. Compounds 3b, 4b were acetylated using acetic anhydride to give the mono- and tri- acetylated products 5a,b; 6a,b, respectively. Compound 1 was reacted with cyanoacetamide and aromatic aldehydes in ammonium acetate or ethyl cyanoactate and aromatic aldehydes in ammonium acetate to give 1,6-naphthyridine- 3-carboxamides 7a-c or 1,6-naphthyridine-3-carboxylates 8a-c, respectively. On the other hand, reaction of compound 1 with aromatic aldehydes and malononitrile in triethylamine afforded the pyrano[3,2-c]pyridine-3- carbonitriles 9a-c. Also, compound 9c was acetylated with acetic anhydride to give the tri-acetylated product 10. Pyrido[4,3-d]pyrimidine-2-thione derivatives 11a-c were obtained by reaction of compound 1 with aromatic aldehydes and thiourea

Issued also as CD

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