Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Analytical Chemistry

The first chapter included the literature review of the reported analyical methods of Lidocaine Hydrochloride, Fluocortolone Pivalate, and Chlorquinaldol. Simultaneous determination of mixtures of the three drugs without prior separation steps was applied using spectrophotometric methods which were either successive or progressive resolution techniques. Successive ratio subtraction was coupled with extended ratio subtraction ,constant multiplication, derivative subtraction coupled constant multiplication, and spectrum subtraction could be applied for the analysis of partially overlapped spectra. On the other hand severely overlapped spectra could be analyzed by constant center and differential dual wavelength for chlorquinaldol, ratio difference and differential derivative ratio for fluocortolone pivalate, while lidocaine hydrochloride was determined by applying constant value via amplitude difference followed by successive ratio subtraction ,and either constant multiplication or constant center followed by spectrum subtraction and successive derivative subtraction. And progressively using amplitude modulation method. Two chemometric-assisted spectrophotometric techniques, principal component regression (PCR) and partial least square (PLS)

Issued also as CD