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Possible protective effect of low-dose gamma irradiation and certain natural products on chemically induced hepatotoxicity in rats / Rasha Refaat Abdelaziz Rashed ; Supervised Sanaa A. Kenawy , Mona A. Elghazaly

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Rasha Refaat Abdelaziz Rashed , 2015Description: 151 P. : facsimiles ; 25cmOther title:
  • التاثير المحتمل لجرعات التشعيع المنخفضة وبعض المنتجات الطبيعية فى الوقاية من الاعتلال الكبدى المحدث كيميائيا فى الجرذان [Added title page title]
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Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology Summary: This study was constructed in order to investigate the hepatoprotective effects offered by each of garlic oil (GO), black seed oil (BO) and sesame oil (SO) each alone or combined with low dose total body gamma (Þ)-irradiation against APAP-induced hepatotoxicity in male albino Wistar rats. To carry out the main study, 96 rats were randomly classified into 2 batches, one of which was subjected to irradiation and the other was kept non-irradiated. The non-irradiated batch was further subclassified into 6 groups. One group served as a normal group, the second group received APAP p.o (1 g/kg). The third, fourth and fifth groups were given either GO (100 mg/kg/day), BO (5 ml/kg/day) or SO (4 ml/kg/day) respectively, orally for 14 days before the induction of hepatotoxicity by APAP. The sixth group received N-acetyl cysteine (NAC, 0.39 g/kg) which was used as a reference hepatoprotective drug. The batch subjected to radiation was further subclassified into six groups. The first group was irradiated at a dose of 0.5 Gy
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Item type Current library Home library Call number Copy number Status Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.09.Ph.D.2015.Ra.P (Browse shelf(Opens below)) Not for loan 01010110066450000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.09.Ph.D.2015.Ra.P (Browse shelf(Opens below)) 66450.CD Not for loan 01020110066450000

Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology

This study was constructed in order to investigate the hepatoprotective effects offered by each of garlic oil (GO), black seed oil (BO) and sesame oil (SO) each alone or combined with low dose total body gamma (Þ)-irradiation against APAP-induced hepatotoxicity in male albino Wistar rats. To carry out the main study, 96 rats were randomly classified into 2 batches, one of which was subjected to irradiation and the other was kept non-irradiated. The non-irradiated batch was further subclassified into 6 groups. One group served as a normal group, the second group received APAP p.o (1 g/kg). The third, fourth and fifth groups were given either GO (100 mg/kg/day), BO (5 ml/kg/day) or SO (4 ml/kg/day) respectively, orally for 14 days before the induction of hepatotoxicity by APAP. The sixth group received N-acetyl cysteine (NAC, 0.39 g/kg) which was used as a reference hepatoprotective drug. The batch subjected to radiation was further subclassified into six groups. The first group was irradiated at a dose of 0.5 Gy

Issued also as CD

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