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A Pharmaceutical study on oral self-nanoemulsifying delivery system of sertraline hydrochloride for enhanced dissolution and bioavailability / Amira Mohsen AbdelKader ; Supervised Mahmoud M. Ghorab , Hussein O. Ammar

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Amira Mohsen AbdelKader , 2015Description: 204 P. : charts , facsimiles ; 25cmOther title:
  • درا{uئإآ٣}{uئإ٩٤} {uئإآآ}{uئإئ٤}{uئإءء}{uئإؤئ}{uئإئ٤}{uئإ٩٤} {uئإؤئ}{uئإآأ}{uئإئ٤}{uئإ٨إ}{uئإأئ}{uئإ٩٤} {uئإإ٣}{uئإآ٤}{uئإ٩٨}{uئإء٤}{uئإإ٠}{uئإ٩٠} {uئإإ٧}{uئإ٨إ}{uئإإ٧}{uئإإإ}{uئإإ٣}{uئإ٩٨}{uئإءإ}ى: {uئإأآ}{uئإ٩٢}{uئإءإ} ا{uئإؤئ}{uئإؤ٤}{uئإإ٢}: {uئإؤئ}{uئإأأ}{uئإؤ٨}{uئإ٨إ}ر إ{uئإئ٣}{uئإءء}رو{uئإؤآ}{uئإإ٠}{uئإإإ}ر{uئإئ٣}{uئإءء} ا{uئإؤئ}{uئإآ٤}{uئإءإ}{uئإ٩٧}{uئإءإ}ا{uئإؤئ}{uئإئ٤}{uئإإ٦} {uئإؤئ}{uئإآ٠}{uئإئ٣}{uئإ٨إ}دة {uئإإ٣}{uئإأأ}{uئإءء}ل ا{uئإؤئ}{uئإءأ}و{uئإ٩١}{uئإ٨إ}ن و ا{uئإؤئ}{uئإ٩٨}{uئإإإ}ا{uئإؤ٣}{uئإءإ} ا{uئإؤئ}{uئإء٤}{uئإئ٤}{uئإإإ}ى [Added title page title]
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Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics Summary: The objective of the present investigation was to develop and characterize self-nanoemulsifying drug delivery system of sertraline hydrochloride (SNEDDS). Sertraline hydrochloride is a poorly water soluble drug used for the treatment of depression of the selective serotonin reuptake inhibitor class (SSRI). Solubility of sertraline hydrochloride in various vehicles were determined, and ternary phase diagrams were constructed using a suitable oil, surfactant and cosurfactant system to find out the most efficient self- emulsification system. Capmul® and Lauroglycol® were selected as the oil phase, Tween 80 and Cremophor® as surfactant and Transcutol® as cosurfactant due to their high solublization effect. Various formulations were prepared by simply mixing followed by vortexing. These formulations were characterized by solubility of the drug in the vehicle, particle size of the dispersed emulsion, zeta potential and drug release profile. Ternary phase diagrams were used to evaluate the emulsification domain
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.08.Ph.D.2015.Am.P (Browse shelf(Opens below)) Not for loan 01010110066616000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.08.Ph.D.2015.Am.P (Browse shelf(Opens below)) 66616.CD Not for loan 01020110066616000

Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics

The objective of the present investigation was to develop and characterize self-nanoemulsifying drug delivery system of sertraline hydrochloride (SNEDDS). Sertraline hydrochloride is a poorly water soluble drug used for the treatment of depression of the selective serotonin reuptake inhibitor class (SSRI). Solubility of sertraline hydrochloride in various vehicles were determined, and ternary phase diagrams were constructed using a suitable oil, surfactant and cosurfactant system to find out the most efficient self- emulsification system. Capmul® and Lauroglycol® were selected as the oil phase, Tween 80 and Cremophor® as surfactant and Transcutol® as cosurfactant due to their high solublization effect. Various formulations were prepared by simply mixing followed by vortexing. These formulations were characterized by solubility of the drug in the vehicle, particle size of the dispersed emulsion, zeta potential and drug release profile. Ternary phase diagrams were used to evaluate the emulsification domain

Issued also as CD

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