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Genetic Variations in Visfatin and Resistin Genes in Egyptian Type 2 Diabetic Patients With and Without Complications / Zeinab Mohamed Abdelnasser ; Supervised Tarek M. Kamal Motawi ,Olfat Gamil Shaker , Maha Mahmoud Elsawalhi

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Zeinab Mohamed Abdelnasser , 2015Description: 161 P. : charts ; 25cmOther title:
  • الإختلافات الوراثية في جينات الفسفاتين و الريسستين في المرضي المصريين المصابين بالبول السكري من النوع الثاني بمضاعفات و بدون مضاعفات [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Biochemistry Summary: Diabetes mellitus is one of the main threats to human health in the twenty-first century. Visfatin and resistin are adipokines which have been implicated in the pathogenesis of type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD) complications. Several genetic studies have shown inconsistent results regarding association of visfatin and resistin gene polymorphisms with T2DM and CVD complications. Subjects and methods: Here we investigate whether visfatin -948G/T and resistin -420C/G polymorphisms are associated with T2DM, its CVD complications and serum adipokine levels in 90 Egyptian diabetic patients (44 without CVD and 46 with CVD) along with 60 healthy control subjects. Polymorphisms of visfatin -948G/T and resistin-420C/G genes were detected by Real time-PCR and PCR-RFLP, respectively. Serum visfatin and resistin were measured by ELISA. Results: Higher frequencies of visfatin -948G/T and resistin -420C/G were observed among T2DM patients compared to controls
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.01.M.Sc.2015.Ze.G (Browse shelf(Opens below)) Not for loan 01010110066619000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.01.M.Sc.2015.Ze.G (Browse shelf(Opens below)) 66619.CD Not for loan 01020110066619000

Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Biochemistry

Diabetes mellitus is one of the main threats to human health in the twenty-first century. Visfatin and resistin are adipokines which have been implicated in the pathogenesis of type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD) complications. Several genetic studies have shown inconsistent results regarding association of visfatin and resistin gene polymorphisms with T2DM and CVD complications. Subjects and methods: Here we investigate whether visfatin -948G/T and resistin -420C/G polymorphisms are associated with T2DM, its CVD complications and serum adipokine levels in 90 Egyptian diabetic patients (44 without CVD and 46 with CVD) along with 60 healthy control subjects. Polymorphisms of visfatin -948G/T and resistin-420C/G genes were detected by Real time-PCR and PCR-RFLP, respectively. Serum visfatin and resistin were measured by ELISA. Results: Higher frequencies of visfatin -948G/T and resistin -420C/G were observed among T2DM patients compared to controls

Issued also as CD

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