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Design, synthesis and biological evaluation of novel quinazoline derivatives and acyclic analogues as antineoplastic Agents / Ghada Fathy Hussien Elmasry ; Supervised Nehad Aboulmagdel Sayed , Amal Abdelhaleem Eissa , Reem Khidr Arafa

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Ghada Fathy Hussien Elmasry , 2015Description: 146 P. : facsimiles ; 25cmOther title:
  • تصميم و تشييد و تقييم الفاعلية البيولوجية لمشتقات كينازولين مستحدثة و نظائرها اللاحلقية كمضادات للأورام [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutical Chemistry Summary: This work deals with the design and synthesis of some novel 6-iodo-2-(pyridin-3/4- yl)-3-substituted quinazolinone derivatives 8a-l, 10a-h, 13-18 in addition to certain acyclic analogues 9a-n and 12a-h. The in vitro cytotoxic activity of the synthesized compounds was performed against several cancer cell lines. Compounds eliciting superior cytotoxicity were further subjected to in vivo study. Kinase inhibitory assay was also carried out to investigate the mechanism of action of the target compounds and they displayed the highest activity against ABL kinase. Finally, a molecular modeling study was performed to figure out the interaction of some selected new compounds with the active site of ABL kinase
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.05.M.Sc.2015.Gh.D (Browse shelf(Opens below)) Not for loan 01010110066621000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.05.M.Sc.2015.Gh.D (Browse shelf(Opens below)) 66621.CD Not for loan 01020110066621000

Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutical Chemistry

This work deals with the design and synthesis of some novel 6-iodo-2-(pyridin-3/4- yl)-3-substituted quinazolinone derivatives 8a-l, 10a-h, 13-18 in addition to certain acyclic analogues 9a-n and 12a-h. The in vitro cytotoxic activity of the synthesized compounds was performed against several cancer cell lines. Compounds eliciting superior cytotoxicity were further subjected to in vivo study. Kinase inhibitory assay was also carried out to investigate the mechanism of action of the target compounds and they displayed the highest activity against ABL kinase. Finally, a molecular modeling study was performed to figure out the interaction of some selected new compounds with the active site of ABL kinase

Issued also as CD

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