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Diagnostic value of F18 FDG PET-CT compared to I-131 mibg in pediatric Neuroblastoma patients / Mai Amr Abdelwahab Ali ; Supervised Hosna Moustafa , Walid Omar , Magdy Kotb

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Mai Amr Abdelwahab Ali , 2015Description: 137 P. : charts , facsimiles ; 25cmOther title:
  • فى اورام النيوروبلاستوماMIBG القيمة التشخيصية لاستعمال المسح الذرى البوزيترونى المدمج مع الاشعة المقطعية بمسح اليود المشع 131المحمل بال [Added title page title]
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Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Medicine- Department of Nuclear Medicine Summary: neuroblastoma and several studies have looked at the utility of MIBG for staging and have compared MIBG with other diagnostic modalities. F-18 FDG/PET CT is able to characterize neuroendocrinal tumours subtypes, which varies in aggressiveness from well to poorly differentiated phenotypes, through its ability to quantify glycolytic metabolism. In our study we were able to compare the diagnostic performance of both I-131 MIBG & F18 FDG PET/CT where site based analysis was performed. A wide range of sensitivity variation was noted with I-131 MIBG, where higher sensitivity was seen at local sites (83% for primary & 69 % for regional LNs) compared to 45 % for distant soft tissue metastases with global soft tissue lesions detection sensitivity 70.1%. On the other hand, No significant site related altered sensitivity was seen with FDG PET/CT where sensitivity ranges from 93 to 100 % at different sites. This gap of sensitivity between both modalities was statistically significant. High specificity (100 %) was expected from the neuroblastoma specific tracer (MIBG) yet with no significant statistical difference from FDG PET/CT
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Item type Current library Home library Call number Copy number Status Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.22.Ph.D.2015.Ma.D (Browse shelf(Opens below)) Not for loan 01010110066638000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.22.Ph.D.2015.Ma.D (Browse shelf(Opens below)) 66638.CD Not for loan 01020110066638000

Thesis (Ph.D.) - Cairo University - Faculty of Medicine- Department of Nuclear Medicine

neuroblastoma and several studies have looked at the utility of MIBG for staging and have compared MIBG with other diagnostic modalities. F-18 FDG/PET CT is able to characterize neuroendocrinal tumours subtypes, which varies in aggressiveness from well to poorly differentiated phenotypes, through its ability to quantify glycolytic metabolism. In our study we were able to compare the diagnostic performance of both I-131 MIBG & F18 FDG PET/CT where site based analysis was performed. A wide range of sensitivity variation was noted with I-131 MIBG, where higher sensitivity was seen at local sites (83% for primary & 69 % for regional LNs) compared to 45 % for distant soft tissue metastases with global soft tissue lesions detection sensitivity 70.1%. On the other hand, No significant site related altered sensitivity was seen with FDG PET/CT where sensitivity ranges from 93 to 100 % at different sites. This gap of sensitivity between both modalities was statistically significant. High specificity (100 %) was expected from the neuroblastoma specific tracer (MIBG) yet with no significant statistical difference from FDG PET/CT

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