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Effect of pioglitazone alone or in combination with some natural products in fructose - induced metabolic syndrome in Rats / Sherehan Mohamed Ibrahim Eldesoky ; Supervised Ezz Eldin Eldenshary , Dalaal Moustafa Abdallah

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Sherehan Mohamed Ibrahim Eldesoky , 2015Description: 183 P. : charts , facsimiles ; 25cmOther title:
  • تأثير دواء بيوجليتازون منفردا أو مع بعض المواد الطبيعية فى الجرذان المحدث فيها المتلازمة الأيضية باستخدام الفركتوز [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology Summary: Metabolic syndrome (MetS) is mainly mediated by disruptions of prooxidant/antioxidant as well as inflammatory status. This study aimed to test the potential anti - MetS effects of pioglitazone (PIO), methyl sulfonyl methane (MSM), geraniol (GO), as well as the combination of MSM or GO with PIO low dose. Rats were divided into 8 groups; the control group, the MetS group, and two groups received PIO (5 and 10 mg/Kg), MSM group (400 mg/Kg), GO group (250 mg / Kg), and two groups were given PIO low dose combined with MSM and GO. All drugs were given orally for four weeks after 16 weeks administration of (10%) fructose solution to induce MetS. Administration of the aforementioned treatments showed an improvement in most of MetS criteria. These were signified by reduction in liver, visceral, and epididymal fat indices as well as body weight
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.09.M.Sc.2015.Sh.E (Browse shelf(Opens below)) Not for loan 01010110066806000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.09.M.Sc.2015.Sh.E (Browse shelf(Opens below)) 66806.CD Not for loan 01020110066806000

Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology

Metabolic syndrome (MetS) is mainly mediated by disruptions of prooxidant/antioxidant as well as inflammatory status. This study aimed to test the potential anti - MetS effects of pioglitazone (PIO), methyl sulfonyl methane (MSM), geraniol (GO), as well as the combination of MSM or GO with PIO low dose. Rats were divided into 8 groups; the control group, the MetS group, and two groups received PIO (5 and 10 mg/Kg), MSM group (400 mg/Kg), GO group (250 mg / Kg), and two groups were given PIO low dose combined with MSM and GO. All drugs were given orally for four weeks after 16 weeks administration of (10%) fructose solution to induce MetS. Administration of the aforementioned treatments showed an improvement in most of MetS criteria. These were signified by reduction in liver, visceral, and epididymal fat indices as well as body weight

Issued also as CD

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