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A Pharmaceutical study on improving the oral bioavailability of an anti - hyperlipidimic drug / Wessam Hamdy Abdelsalam ; Supervised Saadia Ahmed Tayel , Mohamed Ahmed Elnabarawi , Mina Tadros

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Wessam Hamdy Abdelsalam , 2015Description: 244 P. : charts ; 25cmOther title:
  • دراسة صيدلية على تحسين الاتاحة الحيوية الفموية لعقار مخفض للدهون [Added title page title]
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Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics Summary: Hypercholesterolemia is the presence of high levels of cholesterol in the blood. It is typically due to a combination of environmental and genetic factors. Environmental factors include obesity, alcohol and diabetes mellitus. Genetic factors include mutations in specific genes; the most common is the LDL - R gene that encodes the LDL receptor protein; which normally removes LDL from the circulation. Longstanding elevation of serum cholesterol can lead to atherosclerosis. Pravastatin sodium (PVS) belongs to the statins class. PVS is a lipoprotein-lowering drug that inhibits HMG - CoA reductase; the rate - limiting step in the biosynthesis of cholesterol. PVS suffers from some limitations; including, (i) The short elimination half-life ranging from 1 - 3 h, (ii) The instability under the gastric acidity through conversion to isomers with markedly lower activities, (iii) The low permeability through the intestinal membrane due to its hydrophilic properties and (iv) The extensive hepatic first pass metabolism resulting in low oral bioavailability 18%
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.08.Ph.D.2015.We.P (Browse shelf(Opens below)) Not for loan 01010110066807000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.08.Ph.D.2015.We.P (Browse shelf(Opens below)) 66807.CD Not for loan 01020110066807000

Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics

Hypercholesterolemia is the presence of high levels of cholesterol in the blood. It is typically due to a combination of environmental and genetic factors. Environmental factors include obesity, alcohol and diabetes mellitus. Genetic factors include mutations in specific genes; the most common is the LDL - R gene that encodes the LDL receptor protein; which normally removes LDL from the circulation. Longstanding elevation of serum cholesterol can lead to atherosclerosis. Pravastatin sodium (PVS) belongs to the statins class. PVS is a lipoprotein-lowering drug that inhibits HMG - CoA reductase; the rate - limiting step in the biosynthesis of cholesterol. PVS suffers from some limitations; including, (i) The short elimination half-life ranging from 1 - 3 h, (ii) The instability under the gastric acidity through conversion to isomers with markedly lower activities, (iii) The low permeability through the intestinal membrane due to its hydrophilic properties and (iv) The extensive hepatic first pass metabolism resulting in low oral bioavailability 18%

Issued also as CD

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