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Utilization of urea and its derivatives in the synthesis of heterocyclic compounds with anticipated biological activity / Samia Ali Mohamed Ali Elseginy ; Supervised Kamilia Mahmoud Amin , Galal Abdelmohin Nawwar

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Samia Ali Mohamed Ali Elseginy , 2015Description: 181 P. ; 25cmOther title:
  • استخدام اليوريا و مشتقاتها فى تشييد مركبات غير متجانسه الحلقه من المتوقع ان يكون لها تأثير بيولوجى [Added title page title]
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Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutical Chemistry Summary: Despite recent progress in anti - breast cancer therapy, there's still urgent need to search for newer and safer anticancer agents. Encouraged by the marked cytotoxic activity exhibited by some urea derivatives, adapting different mechanism of actions, it seemed of interest to synthesize and investigate the anti-breast cancer activity of different series of urea derivatives, with the objective of discovering novel dual HER2 / HER1 kinase inhibitor as anti - breast cancer. Thus in this study, computer aided drug design techniques were adapted, virtual screening and fragment based drug design techniques to discover urea derivative as lead HER2 / HER1 kinase inhibitor. In addition, we have synthesized series of quinazoline - 2 - ylamino - pyrimidine (cyclic guanidine), symmetric diarylurea derivatives, unsymmetric diarylthiourea derivatives, diarylsulfonylurea drivatives, aryl - heterocyclic - semicarbzide derivatives and oxadiazole derivatives as HER2 / HER1 kinase inhibitor
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.05.Ph.D.2015.Sa.U (Browse shelf(Opens below)) Not for loan 01010110066809000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.05.Ph.D.2015.Sa.U (Browse shelf(Opens below)) 66809.CD Not for loan 01020110066809000

Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutical Chemistry

Despite recent progress in anti - breast cancer therapy, there's still urgent need to search for newer and safer anticancer agents. Encouraged by the marked cytotoxic activity exhibited by some urea derivatives, adapting different mechanism of actions, it seemed of interest to synthesize and investigate the anti-breast cancer activity of different series of urea derivatives, with the objective of discovering novel dual HER2 / HER1 kinase inhibitor as anti - breast cancer. Thus in this study, computer aided drug design techniques were adapted, virtual screening and fragment based drug design techniques to discover urea derivative as lead HER2 / HER1 kinase inhibitor. In addition, we have synthesized series of quinazoline - 2 - ylamino - pyrimidine (cyclic guanidine), symmetric diarylurea derivatives, unsymmetric diarylthiourea derivatives, diarylsulfonylurea drivatives, aryl - heterocyclic - semicarbzide derivatives and oxadiazole derivatives as HER2 / HER1 kinase inhibitor

Issued also as CD

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