Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology

Hepatic ischemia-reperfusion (IR) injury is a serious clinical problem involving a cascade of events that ultimately leads to cellular damage and organ dysfunction. Oxidative stress has been implicated as one of the possible mechanisms of IR induced hepatotoxicity. The present study aimed to examine the ability of trimetazidine, taurine, silymarin, sodium selenite and telluric acid to protect against IR - induced oxidative stress and hepatotoxicity. IR was induced in rats by clamping the hepatic artery and portal vein for 30 min followed by 1 h of reperfusion. Male Wistar rats were classified into 7 groups (n = 8): Normal control, IR control, trimetazidine (20 mg / kg; i.p.), taurine (200 æg / kg; i.p.), silymarin (200 mg / kg; p.o.), sodium selenite (50 æg / kg; i.p.) and telluric acid (50 æg/kg; i.p.). Treatments were conducted for 7 consecutive days before induction of IR. Hepatic IR injury increased plasma aminotransferases and lactate dehydrogenase activities as well as hepatic lipid peroxides and nitric oxide contents coupled by decrease in reduced glutathione content and inhibition of glutathione peroxidase activity

Issued also as CD