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Synthesis and anticonvulsant evaluation of certain substituted diazaspirocyloalkane diones / Walaa Hamada Abdalla Abdelhamid ; Supervised Mohamed Nabil Youssef Aboul-Enein , Fatma Abdelfattah Ragab

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Walaa Hamada Abdalla Abdelhamid , 2015Description: 120 P. : facsimiles ; 25cmOther title:
  • تشييد و تقييم الفاعليه المضاده للتشنجات لمشتقات دايازاسبيروسيكلوالكان داى اون [Added title page title]
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Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutical Chemistry Summary: The present investigation deals with the synthesis of 6-aryl-9-substituted-6,9-diazaspiro-[4,5]decane-8,10-diones (VIa-i) and 1-aryl-4-substituted -1,4-diazaspiro[5.5]undecane-3,5-diones (VIm-u), 6-aryl-9-(1H-tetrazol-5-yl)methyl)-6,9-diazaspiro[4.5]decane-8,10-diones (VIj-l) and 1-aryl-4-((1H-tetrazol-5-yl)methyl)-1,4-diazaspiro[5.5] undecane-3,5-diones (VIv-x). The anticonvulsant activity was studied using subcutaneous pentylenetetrazole (ScPTZ) test, Maximal electroshock seizure (MES) test and Neurotoxity test. The molecular modeling part was done through pharmacophore generation using Discovery Studio 2.5 software (Accelerys, Inc.: San Diego, CA.). The thesis is divided into the following sections: Introduction This section includes a review on the chemistry and biological profile of diketopiperazines (DKPs) in addition to the biological profiles of disubstituted cycloalkanes. Basis of the present investigation This part rationalizes and describes the pharmacological basis on which the synthesized compounds were selected to be studied as anticonvulsants, in addition to the schemes followed in their synthesis (Schemes 1-3)
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.05.Ph.D.2015.Wa.S (Browse shelf(Opens below)) Not for loan 01010110066883000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.05.Ph.D.2015.Wa.S (Browse shelf(Opens below)) 66883.CD Not for loan 01020110066883000

Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutical Chemistry

The present investigation deals with the synthesis of 6-aryl-9-substituted-6,9-diazaspiro-[4,5]decane-8,10-diones (VIa-i) and 1-aryl-4-substituted -1,4-diazaspiro[5.5]undecane-3,5-diones (VIm-u), 6-aryl-9-(1H-tetrazol-5-yl)methyl)-6,9-diazaspiro[4.5]decane-8,10-diones (VIj-l) and 1-aryl-4-((1H-tetrazol-5-yl)methyl)-1,4-diazaspiro[5.5] undecane-3,5-diones (VIv-x). The anticonvulsant activity was studied using subcutaneous pentylenetetrazole (ScPTZ) test, Maximal electroshock seizure (MES) test and Neurotoxity test. The molecular modeling part was done through pharmacophore generation using Discovery Studio 2.5 software (Accelerys, Inc.: San Diego, CA.). The thesis is divided into the following sections: Introduction This section includes a review on the chemistry and biological profile of diketopiperazines (DKPs) in addition to the biological profiles of disubstituted cycloalkanes. Basis of the present investigation This part rationalizes and describes the pharmacological basis on which the synthesized compounds were selected to be studied as anticonvulsants, in addition to the schemes followed in their synthesis (Schemes 1-3)

Issued also as CD

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