Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Radio-diagnosis

To review the impact of maternal pre gestational and gestational diabetes on fetal cardiac morphology and function through assessment of cardiac structure, ventricular myocardial and septal hypertrophy and overall systolic and diastolic cardiac function using left modified myocardial performance index. Twenty diabetic mothers and 30 control ones between 28 and 40 weeks gestational age. Fetal echocardiogram was done for diabetic patients, basic and extended basic cardiac exam for control cases. 2D measurement of end diastolic thickness of inter ventricular septum and ventricular myocardial free walls for all subjects with assessment of cardiac function using left modified myocardial performance index. Statistically significant difference was detected between diabetic and control cases regarding septal and myocardial thickness denoting onset of fetal diabetic hypertrophic cardiomyopathy. Statistically significant left myocardial performance index between the 2 groups was found denoting impaired fetal cardiac overall systolic and diastolic function. One of the diabetic mothers was diagnosed with visceral heterotaxy syndrome - left isomerism

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