Role of graft biopsy in pediatric renal transplant recepients / Fatema Mohammad Atia Abdelaziz ; Supervised Hafez Mahmoud Bazaraa , Mohamed Gamal Eldin Saadi , Sawsan Abdalmonem Fadda

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Fatema Mohammad Atia Abdelaziz

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TextLanguage: English Publication details: Cairo : Fatema Mohammad Atia Abdelaziz , 2015Description: 149 P. : charts , facsimiles ; 25cmOther title:

دور الخزعة الكلوية فى متلقى زراعة الكلى من الأطفال [Added title page title]

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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pediatrics Summary: Kidney transplantation is the treatment of choice for end stage renal disease (ESRD). Nevertheless, renal allograft dysfunction is still common after transplantation and may be caused by rejection, calcineurin inhibitor (CNI) toxicity, recurrent or denovo renal disease. Graft biopsy is often used to determine its causes. In this study, ultrasound guided biopsy was done and studied pathologically. Acute rejection was found in 7 cases (23%) and interstitial fibrosis and tubular atrophy (IFTA) of various grades in 16%. Immunotherapy was modified in 28 cases (90%) following biopsy. Chronic score correlated with both timing post transplantation and creatinine rise over baseline (p = 0.028, p = 0.037 respectively) allograft biopsy represents an indispensable diagnostic tool with significant impact on management approach

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Item type	Current library	Home library	Call number	Copy number	Status	Date due	Barcode
Thesis	قاعة الرسائل الجامعية - الدور الاول	المكتبة المركزبة الجديدة - جامعة القاهرة	Cai01.11.28.M.Sc.2015.Fa.R (Browse shelf(Opens below))		Not for loan		01010110066954000
CD - Rom	مخـــزن الرســائل الجـــامعية - البدروم	المكتبة المركزبة الجديدة - جامعة القاهرة	Cai01.11.28.M.Sc.2015.Fa.R (Browse shelf(Opens below))	66954.CD	Not for loan		01020110066954000

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Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pediatrics

Kidney transplantation is the treatment of choice for end stage renal disease (ESRD). Nevertheless, renal allograft dysfunction is still common after transplantation and may be caused by rejection, calcineurin inhibitor (CNI) toxicity, recurrent or denovo renal disease. Graft biopsy is often used to determine its causes. In this study, ultrasound guided biopsy was done and studied pathologically. Acute rejection was found in 7 cases (23%) and interstitial fibrosis and tubular atrophy (IFTA) of various grades in 16%. Immunotherapy was modified in 28 cases (90%) following biopsy. Chronic score correlated with both timing post transplantation and creatinine rise over baseline (p = 0.028, p = 0.037 respectively) allograft biopsy represents an indispensable diagnostic tool with significant impact on management approach

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