Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Cardiology

Methods: Thirty patients with isolated moderate to severe MS, 30 patients with isolated moderate to severe MR and normal left ventricular ejection fraction (LVEF) ({u2265} 55%) and 30 healthy controls were compared using one way analysis of variance (ANOVA) test with post-hoc multiple two-group comparisons.LA reservoir strain was calculated as peak systolic atrial longitudinal strain (PALS), LA reservoir strain rate (SR S) as peak systolic positive value, LA conduit SR (SR E) as the early diastolic negative peak, and LA contractile SR(SR A) as the late diastolic negative peak with QRS onset as the reference point. The time from QRS onset to peak systolic longitudinal strain (TTP strain), peak SRS (TTP SRS), peak SRE (TTP SRE) and peak SRA (TTP SRA) were also calculated. The average PALS, different average SR and different time intervals were calculated as the average of LA 6 equidistant segments in the four-chamber view. Results: By ANOVA, there was a statistically significant difference between the LA average PALS (p=0.000), SRS (p=0.000), SRE (p=0.000), SRA (p=0.000), TTP strain (p=0.008), and TTP SRE (p=0.006) of the 2 patient groups and controls. By post-hoc analysis, the LA average PALS, SRS, SRE and SRA were significantly lower in MS patients (all p=0.000) and in MR patients (all p=0.000) compared to controls. TTP SRE was significantly shorter in MR patients compared to controls (p=0.02). LA average PALS was significantly higher in MR compared to MS patients (p=0.02)

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