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Comparative study of some techniques used in scale up of certain tablet formulation / Wessam Adel Fouad ; Supervised Alia Abdellatif Badawi , Ehab Rasmy Bendas

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Wessam Adel Fouad , 2015Description: 200 P. : charts , facsimiles ; 25cmOther title:
  • دراسة مقارنة لبعض التقنيات المستخدمة في نطاق التدريج العلوى لصياغة بعض الأقراص [Added title page title]
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  • Issued also as CD
Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics Summary: The purpose of this work was to conduct comparative study between high shear granulator and fluid bed granulator in the preparation of tablets containing combination of lamivudine and zidovudine .The tablets produced by both techniques were evaluated for physical and chemical characteristics. The work of this thesis showed the advantage of formulation of lamivudine &zidovudine tablets by spraying the powder in the fluidized bed dryer instead of powder granulation in the high shear mixer granulator. The Results showed better dissolution together with higher hardness & better friability for tablets produced by Fluidized bed dryer technique. The tablets kept at Long term and accelerated stability stability conditions are conforming to specification, and the results shown in the validation study confirm that the proposed method for analysis of Lamivudine & Zidovudine in the film coated tablets is valid method
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.08.M.Sc.2015.We.C (Browse shelf(Opens below)) Not for loan 01010110067080000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.08.M.Sc.2015.We.C (Browse shelf(Opens below)) 67080.CD Not for loan 01020110067080000

Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics

The purpose of this work was to conduct comparative study between high shear granulator and fluid bed granulator in the preparation of tablets containing combination of lamivudine and zidovudine .The tablets produced by both techniques were evaluated for physical and chemical characteristics. The work of this thesis showed the advantage of formulation of lamivudine &zidovudine tablets by spraying the powder in the fluidized bed dryer instead of powder granulation in the high shear mixer granulator. The Results showed better dissolution together with higher hardness & better friability for tablets produced by Fluidized bed dryer technique. The tablets kept at Long term and accelerated stability stability conditions are conforming to specification, and the results shown in the validation study confirm that the proposed method for analysis of Lamivudine & Zidovudine in the film coated tablets is valid method

Issued also as CD

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