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A Pharmacognostical Study of artemisia annua L. (family Asteraceae) cultivated in Egypt / Sarah Samir Mohamed Gharib Abdullah ; Supervised Hesham I. Elaskary , Meselhy R. M. Zayed , Hamida M. A. Elgohari

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Sarah Samir Mohamed Gharib Abdullah , 2015Description: 169 P. : charts , facsimiles ; 25cmOther title:
  • دراسة عقاقيرية لنبات أرتيميزيا أنيوا(العائلة المركبة) المنزرع فى مصر [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmacognosy Summary: Artemisia annua L. has been used in China for more than 2000 years for treating many disorders including malaria, A. annua leaves are the main source for the production of artemisinin (the drug of choice for malaria). The present work including botanical identification of the plant material and DNA finger print of the leaves were carried out, to confirm identity of the drug. Phytochemical screening revealed the presence of flavonoids, sterols and/ or triterpenes, carbohydrates, tannins and volatile oil The alcoholic extract of the leaves was found to be safe (LD50 value = 4 gm/kg b.wt.), and the ethyl acetate fraction showed significant hepatoprotective, anti-hyperglycemic and antioxidant activities. Further investigation of the polar fractions; ethyl acetate and n-butanol soluble fractions, resulted in the isolation and identification of 5 major quinic acid derivatives: 3,5-dicaffoeylquinic acid, 4,5-dicaffoeylquinic acid, 3,4- dicaffoeylquinic acid, 3,4-dicaffoeylquinic acid methyl ester and 3- feruloeylquinic acid.
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.07.M.Sc.2015.Sa.P (Browse shelf(Opens below)) Not for loan 01010110067083000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.07.M.Sc.2015.Sa.P (Browse shelf(Opens below)) 67083.CD Not for loan 01020110067083000

Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmacognosy

Artemisia annua L. has been used in China for more than 2000 years for treating many disorders including malaria, A. annua leaves are the main source for the production of artemisinin (the drug of choice for malaria). The present work including botanical identification of the plant material and DNA finger print of the leaves were carried out, to confirm identity of the drug. Phytochemical screening revealed the presence of flavonoids, sterols and/ or triterpenes, carbohydrates, tannins and volatile oil The alcoholic extract of the leaves was found to be safe (LD50 value = 4 gm/kg b.wt.), and the ethyl acetate fraction showed significant hepatoprotective, anti-hyperglycemic and antioxidant activities. Further investigation of the polar fractions; ethyl acetate and n-butanol soluble fractions, resulted in the isolation and identification of 5 major quinic acid derivatives: 3,5-dicaffoeylquinic acid, 4,5-dicaffoeylquinic acid, 3,4- dicaffoeylquinic acid, 3,4-dicaffoeylquinic acid methyl ester and 3- feruloeylquinic acid.

Issued also as CD

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