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Plasma and tissue osteopontin expression in cutaneous lichen planus and its relation to metabolic syndrome / Mohammad AbdAllah Ibrahim Awad ; Supervised Amr Ezz Edin Sharaf , Naglaa Mohamed Sameh Zaki , Dina M. Kadry Ismail

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Mohammad AbdAllah Ibrahim Awad , 2015Description: 177 P. : facsimiles ; 25cmOther title:
  • مستوي الأستيوبنتين في البلازما والأنسجة في الحزاز المسطح الجلدي وعلاقته بمتلازمة الأيض [Added title page title]
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Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Dermatology Summary: Lichen planus (LP) is a chronic inflammatory disease that affects the skin, mucous membranes and appendages. Although its pathogenesis is still unclear, some studies showed that autoreactive cytotoxic T lymphocytes are the effector cells which cause degeneration and destruction of keratinocytes. Osteopontin (OPN) is expressed during inflammation by natural killer cells, activated T cells and macrophages and classified as a T-helper type 1 (Th1) cytokine. Plasma OPN has been reported to be a potential clinical marker for prediction of atherosclerosis. The aim of this study was to investigate the plasma and tissue levels of OPN and plasma selenium levels in patients with LP, to determine their possible role in its pathogenesis and their relation to the metabolic status in patients and to identify a possible link between these markers and co-morbidities observed. The levels of plasma and tissue OPN were measured in LP patients and in the control by ELISA technique from 30 patients with LP as well as from 30 age and sex matched controls. Metabolic syndrome parameters were also was assessed in both groups
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.10.Ph.D.2015.Mo.P (Browse shelf(Opens below)) Not for loan 01010110066933000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.10.Ph.D.2015.Mo.P (Browse shelf(Opens below)) 66933.CD Not for loan 01020110066933000

Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Dermatology

Lichen planus (LP) is a chronic inflammatory disease that affects the skin, mucous membranes and appendages. Although its pathogenesis is still unclear, some studies showed that autoreactive cytotoxic T lymphocytes are the effector cells which cause degeneration and destruction of keratinocytes. Osteopontin (OPN) is expressed during inflammation by natural killer cells, activated T cells and macrophages and classified as a T-helper type 1 (Th1) cytokine. Plasma OPN has been reported to be a potential clinical marker for prediction of atherosclerosis. The aim of this study was to investigate the plasma and tissue levels of OPN and plasma selenium levels in patients with LP, to determine their possible role in its pathogenesis and their relation to the metabolic status in patients and to identify a possible link between these markers and co-morbidities observed. The levels of plasma and tissue OPN were measured in LP patients and in the control by ELISA technique from 30 patients with LP as well as from 30 age and sex matched controls. Metabolic syndrome parameters were also was assessed in both groups

Issued also as CD

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