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Spectrophotometric determination of the platelet inhibitor drug clopidogrel bisulfate / Alyaa Ibrahim Magdi Ibrahim Fathy Salim ; Supervised Yousry M. Issa , Sabrein Harbi Mohammed

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Alyaa Ibrahim Magdi Ibrahim Fathy Salim , 2015Description: 74 P. : charts , facsimiles ; 25cmOther title:
  • التقدير الطيفي للعقار المثبط للصفائح الدموية كلوبيدوجريل بايسلفات [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Analytical Chemistry Summary: Two simple and high sensitive spectrophotometric methods have been developed for the quantitative determination of clopidogrel bisulfate (CLPB), in pure form and in pharmaceutical formulations, through H-point standard addition method (HPSAM) which showed suitable abilities to resolve accurately overlapped absorption spectra of the compounds by simultaneous determination of CLPB in its binary mixture with aspirin (ASP), and the other method is ion-pair formation reactions with some sulphonphthalein, e.g. bromophenol blue (BPB), bromocresol purple (BCP), bromocresol green (BCG), and bromoxylenol blue (BXB). The reaction conditions were studied and optimized. The proposed methods are rapid, accurate, sensitive, selective and cost effective and the methods were successfully applied to the analysis of commercial tablets as Plavix®, Borgavix®, and Colsprin® (authentic sample). Statistical treatment of the results was performed with regard to accuracy and precision using student{u2019}s t- and F-tests at 95% confidence level.
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.12.08.M.Sc.2015.Al.S (Browse shelf(Opens below)) Not for loan 01010110067259000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.12.08.M.Sc.2015.Al.S (Browse shelf(Opens below)) 67259.CD Not for loan 01020110067259000

Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Analytical Chemistry

Two simple and high sensitive spectrophotometric methods have been developed for the quantitative determination of clopidogrel bisulfate (CLPB), in pure form and in pharmaceutical formulations, through H-point standard addition method (HPSAM) which showed suitable abilities to resolve accurately overlapped absorption spectra of the compounds by simultaneous determination of CLPB in its binary mixture with aspirin (ASP), and the other method is ion-pair formation reactions with some sulphonphthalein, e.g. bromophenol blue (BPB), bromocresol purple (BCP), bromocresol green (BCG), and bromoxylenol blue (BXB). The reaction conditions were studied and optimized. The proposed methods are rapid, accurate, sensitive, selective and cost effective and the methods were successfully applied to the analysis of commercial tablets as Plavix®, Borgavix®, and Colsprin® (authentic sample). Statistical treatment of the results was performed with regard to accuracy and precision using student{u2019}s t- and F-tests at 95% confidence level.

Issued also as CD

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