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Baalc gene expression in acute myeloid leukemia and its relation with cd34 expression / Hend Abdelhady Nooh Mahmood ; Supervised Tayssir Mohammed Eyada , Hanan Ramadan Nassar , Yomna Mohammed Elmeligui

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Hend Abdelhady Nooh Mahmood , 2015Description: 126 P. : charts ; 25cmOther title:
  • اظهار جين ال( بالك) وعلاقته بال( سي دي34) في حالات سرطان الدم الميلودي الحاد [Added title page title]
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  • Issued also as CD
Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Medicine- Department of Clinical and Chemical Pathology Summary: Brain And Acute Leukemia Cytoplasmic (BAALC) gene over-expression has been reported in acute myeloid leukemia (AML). In the present study, BAALC overexpression was investigated by reverse transcriptase- real time quantitative polymerase chain reaction (RT-PCR) in 48 patients with de novo AML.CD34 expression were also analyzed by immunophenotyping. BAALC over-expression was detected in (50%) of the patients while CD34 was positive in (54.3%).In high BAALC expressers patients, was associated with female sex predominance than low BAALC expressers patients and the difference reach a statistically significant level. High BAALC expression was significantly associated with higher blast percentage in peripheral blood. BAALC over-expression was seen in FAB subtypes MO, M1, M2, M4 and M5 mostly with M1 and M2 and was associated with statistically significant difference between high and low BAALC expressers as regard induction chemotherapy
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.07.M.Sc.2015.He.B (Browse shelf(Opens below)) Not for loan 01010110066942000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.07.M.Sc.2015.He.B (Browse shelf(Opens below)) 66942.CD Not for loan 01020110066942000

Thesis (M.Sc.) - Cairo University - Faculty of Medicine- Department of Clinical and Chemical Pathology

Brain And Acute Leukemia Cytoplasmic (BAALC) gene over-expression has been reported in acute myeloid leukemia (AML). In the present study, BAALC overexpression was investigated by reverse transcriptase- real time quantitative polymerase chain reaction (RT-PCR) in 48 patients with de novo AML.CD34 expression were also analyzed by immunophenotyping. BAALC over-expression was detected in (50%) of the patients while CD34 was positive in (54.3%).In high BAALC expressers patients, was associated with female sex predominance than low BAALC expressers patients and the difference reach a statistically significant level. High BAALC expression was significantly associated with higher blast percentage in peripheral blood. BAALC over-expression was seen in FAB subtypes MO, M1, M2, M4 and M5 mostly with M1 and M2 and was associated with statistically significant difference between high and low BAALC expressers as regard induction chemotherapy

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