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Relation between the presence of interleukin -18 promoter polymorphisms and idiopathic parkinson{u2019}s disease / Ahmad Kamal Shams Eldin ; Supervised Ebtesam Mohammed Fahmy , Amany Mahmoud Rabah , Sahar Abdelatty Sharaf

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Ahmad Kamal Shams Eldin , 2015Description: 128 P. : charts ; 25cmOther title:
  • العلاقة بين وجود تحور مؤسس الإنترلوكين-{u٠٦ئ١}{u٠٦ئ٨} و مرض باركنسون مجهول السبب [Added title page title]
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Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Neurosurgery Summary: The etiology of sporadic parkinson{u2019}s disease (PD) is largely unknown. The contribution of genetic factors to the pathogenesis of PD is supported by the demonstration of the high concordance in twins, increased risk among relatives of PD patients, the existence of familial PD and parkinsonism based on single gene defects. This study aimed to assess the relation between the polymorphisms of interleukin 18 (IL - 18) gene promoter and the incidence of idiopathic PD, and whether these polymorphisms have an impact on clinical presentation or disease severity. Forty - five subjects were included in the study; thirty patients suffering from idiopathic Parkinson{u2019}s disease and fifteen age and sex matched healthy control subjects. Patients were subjected to complete clinical examination and routine laboratory workup. The severity of parkinsonism was assessed using the unified parkinson's disease rating scale (UPDRS). Genetic testing for the IL - 18 gene promoter - 607C / A single nucleotide polymorphisms (SNP) was done for patients and controls using real time polymerase chain reaction PCR technique
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.20.Ph.D.2015.Ah.R (Browse shelf(Opens below)) Not for loan 01010110067232000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.20.Ph.D.2015.Ah.R (Browse shelf(Opens below)) 67232.CD Not for loan 01020110067232000

Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Neurosurgery

The etiology of sporadic parkinson{u2019}s disease (PD) is largely unknown. The contribution of genetic factors to the pathogenesis of PD is supported by the demonstration of the high concordance in twins, increased risk among relatives of PD patients, the existence of familial PD and parkinsonism based on single gene defects. This study aimed to assess the relation between the polymorphisms of interleukin 18 (IL - 18) gene promoter and the incidence of idiopathic PD, and whether these polymorphisms have an impact on clinical presentation or disease severity. Forty - five subjects were included in the study; thirty patients suffering from idiopathic Parkinson{u2019}s disease and fifteen age and sex matched healthy control subjects. Patients were subjected to complete clinical examination and routine laboratory workup. The severity of parkinsonism was assessed using the unified parkinson's disease rating scale (UPDRS). Genetic testing for the IL - 18 gene promoter - 607C / A single nucleotide polymorphisms (SNP) was done for patients and controls using real time polymerase chain reaction PCR technique

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