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Biochemical studies on breast cancer / Mohamed Abdallah Sayed Ahmed Elweresh ; Supervised Sanaa Osman Abdallah , Abdelfattah Mohamed Attallah

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Mohamed Abdallah Sayed Ahmed Elweresh , 2015Description: 176 P. : charts , facsimiles ; 25cmOther title:
  • دارسات كيميائية حيوية على سرطان الثدى [Added title page title]
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Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Science - Department of Biochemistry Summary: Breast cancer is considered the leading cause of cancer death among females in economically developing countries. Tumor markers are biochemical indicators for the presence of tumor. The epithelial membrane antigen (EMA) marker could be used to detect small deposits of malignant cells. This work was concerned with the identification and quantitative determination of EMA and then estimating its performance as surrogate marker for identifying breast cancer. Methods: The circulating level of EMA was determined by Western blot and enzyme linked immunosorbent assay (ELISA) in sera from 102 women with Breast cancer and 90 women as controls (40 with benign breast condition and 50 healthy). Results: EMA at 130 kDa was identified. EMA showed area under receiver-operating characteristic curve (AUC) of 0.946 with 69.6% sensitivity, 94.0% specificity, 96.0% PPV, 60.3% NPV, and 77.6% efficiency. Conclusion: EMA may improve the identification of breast carcinoma with a high degree of accuracy in this group of Egyptian women
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.12.02.Ph.D.2015.Mo.B (Browse shelf(Opens below)) Not for loan 01010110067375000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.12.02.Ph.D.2015.Mo.B (Browse shelf(Opens below)) 67375.CD Not for loan 01020110067375000

Thesis (Ph.D.) - Cairo University - Faculty of Science - Department of Biochemistry

Breast cancer is considered the leading cause of cancer death among females in economically developing countries. Tumor markers are biochemical indicators for the presence of tumor. The epithelial membrane antigen (EMA) marker could be used to detect small deposits of malignant cells. This work was concerned with the identification and quantitative determination of EMA and then estimating its performance as surrogate marker for identifying breast cancer. Methods: The circulating level of EMA was determined by Western blot and enzyme linked immunosorbent assay (ELISA) in sera from 102 women with Breast cancer and 90 women as controls (40 with benign breast condition and 50 healthy). Results: EMA at 130 kDa was identified. EMA showed area under receiver-operating characteristic curve (AUC) of 0.946 with 69.6% sensitivity, 94.0% specificity, 96.0% PPV, 60.3% NPV, and 77.6% efficiency. Conclusion: EMA may improve the identification of breast carcinoma with a high degree of accuracy in this group of Egyptian women

Issued also as CD

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