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Development and validation of analytical methods for the determination of some anti-Hyperlipidemic drugs / Marwa Ahmed Moffid Allam ; Supervised Bahia Abbas Moussa , Asmaa Ahmed Elzaher Mohamed , Hanaa Abdelmonem Hashem

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Marwa Ahmed Moffid Allam , 2015Description: 160 P. : charts ; 25cmOther title:
  • إيجاد طرق تحليلية لتعيين بعض الادوية المخفضة لدهون الدم المرتفعة والتحقق من صلاحيتها [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutical Chemistry Summary: The aim of this work is to develop simple, accurate and precise methods for the determination of some antihyperlipidemic drugs in combination with anti- hypertensives and anti-coagulants. The same was applied with some of their co- administered drugs as elderly people suffer from several health problems, in addition, they are fragile towards overdosing, drug interactions, and low metabolic rates, therefore, determination of multi-prescribed drugs was a goal to achieve. The drugs were analyzed in their bulk powder and in their pharmaceutical dosage form either in combinations or in presence of their impurities and co-administered drugs were determined in plasma. Drugs investigated include Atorvastatin calcium and Rosuvastatin calcium (HMG-CoA reductase inhibitor), Ramipril (angiotensin converting enzyme inhibitor), Atenolol (beta blocker) Aspirin and Clopidogrel (anti-platelet agents) Spectrophotometry was suggested as the most applicable economic method present in all the quality control laboratories. So, two different spectrophotometric methods were applied for the determination of the binary mixture of RS and CP without prior separation. These methods include chemometric methods and mean centering of ratio spectra method
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.05.M.Sc.2015.Ma.D (Browse shelf(Opens below)) Not for loan 01010110067558000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.05.M.Sc.2015.Ma.D (Browse shelf(Opens below)) 67558.CD Not for loan 01020110067558000

Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutical Chemistry

The aim of this work is to develop simple, accurate and precise methods for the determination of some antihyperlipidemic drugs in combination with anti- hypertensives and anti-coagulants. The same was applied with some of their co- administered drugs as elderly people suffer from several health problems, in addition, they are fragile towards overdosing, drug interactions, and low metabolic rates, therefore, determination of multi-prescribed drugs was a goal to achieve. The drugs were analyzed in their bulk powder and in their pharmaceutical dosage form either in combinations or in presence of their impurities and co-administered drugs were determined in plasma. Drugs investigated include Atorvastatin calcium and Rosuvastatin calcium (HMG-CoA reductase inhibitor), Ramipril (angiotensin converting enzyme inhibitor), Atenolol (beta blocker) Aspirin and Clopidogrel (anti-platelet agents) Spectrophotometry was suggested as the most applicable economic method present in all the quality control laboratories. So, two different spectrophotometric methods were applied for the determination of the binary mixture of RS and CP without prior separation. These methods include chemometric methods and mean centering of ratio spectra method

Issued also as CD

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