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Study on the potential antidiabetic effects of trigonelline alone and with vildagliptin in type-2 diabetic model in rats / Amat-Alrazaq Ahmed Ali Aldakinah ; Supervised Hanan Salah Eldin Elabhar , Dalaal Moustafa Abdallah , Muhammad Yusuf Alshorbagy

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Amat-Alrazaq Ahmed Ali Aldakinah , 2015Description: 149 P. : charts , photographs ; 25cmOther title:
  • دراسة حول التاثير المحتمل للترايجونيلين كمضاد لمرض السكري والآليات المحتملة بمفرده أو بمصاحبة فيلداجليبتن في نموذج مرض السكري (النوع الثاني) في الجرذان [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology Summary: Trigonelline is the major alkaloid component of fenugreek that proved antidiabetic efficacy; however its mechanism of action has not yet been elucidated. The objective of this work was to determine the effects of trigonelline and vildagliptin on the altered insulin signaling, glucose hemostasis, and lipid profile in insulin resistance /type 2 diabetic model in rats induced by high-fat/fructose diet (HFFD) for 8 weeks followed by a single sub-diabetogenic dose of streptozotocin (35 mg/kg, i.p.). Trigonelline (50mg/kg, p.o, daily for 4 weeks) decreased body weight, visceral and epididymal fat weight ratios. Moreover, it opposed the HFFD effects lowering serum levels of glucose, insulin, and fructosamine levels, as well as the homeostatic model assessment{u2013}insulin resistance (HOMA- IR) index. Besides, it improved serum total cholesterol and triglycerides, as well as serum alanine and aspartate aminotransferases. In the soleus skeletal muscle, trigonelline elevated insulin receptors autophosphorylation, protein kinase B, glucose transporter 4 (GLUT4), and glutathione. In addition, it decreased soleus skeletal muscle advanced glycation end products (AGE), free fatty acids (FFAs), triglycerides, and lipid peroxides. Likewise, diabetic groups treated with both doses of vildagliptin (3 and 10mg/kg, p.o, daily for 4 weeks) showed noticeable improvements in the aforesaid parameters. In conclusion, the present study demonstrates that trigonelline significantly improved glucose and lipid homeostasis in insulin resistant/diabetic animals by improving insulin sensitivity via enhanced GLUT4 and the inhibition of FFAs, and AGE as well as its antioxidant potential in the soleus skeletal muscle
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.09.M.Sc.2015.Am.S (Browse shelf(Opens below)) Not for loan 01010110067390000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.09.M.Sc.2015.Am.S (Browse shelf(Opens below)) 67390.CD Not for loan 01020110067390000

Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology

Trigonelline is the major alkaloid component of fenugreek that proved antidiabetic efficacy; however its mechanism of action has not yet been elucidated. The objective of this work was to determine the effects of trigonelline and vildagliptin on the altered insulin signaling, glucose hemostasis, and lipid profile in insulin resistance /type 2 diabetic model in rats induced by high-fat/fructose diet (HFFD) for 8 weeks followed by a single sub-diabetogenic dose of streptozotocin (35 mg/kg, i.p.). Trigonelline (50mg/kg, p.o, daily for 4 weeks) decreased body weight, visceral and epididymal fat weight ratios. Moreover, it opposed the HFFD effects lowering serum levels of glucose, insulin, and fructosamine levels, as well as the homeostatic model assessment{u2013}insulin resistance (HOMA- IR) index. Besides, it improved serum total cholesterol and triglycerides, as well as serum alanine and aspartate aminotransferases. In the soleus skeletal muscle, trigonelline elevated insulin receptors autophosphorylation, protein kinase B, glucose transporter 4 (GLUT4), and glutathione. In addition, it decreased soleus skeletal muscle advanced glycation end products (AGE), free fatty acids (FFAs), triglycerides, and lipid peroxides. Likewise, diabetic groups treated with both doses of vildagliptin (3 and 10mg/kg, p.o, daily for 4 weeks) showed noticeable improvements in the aforesaid parameters. In conclusion, the present study demonstrates that trigonelline significantly improved glucose and lipid homeostasis in insulin resistant/diabetic animals by improving insulin sensitivity via enhanced GLUT4 and the inhibition of FFAs, and AGE as well as its antioxidant potential in the soleus skeletal muscle

Issued also as CD

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