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Synthesis of some new sulfonamide derivatives of expected anticancer and radiosensitizing activities / Sally Samir Mohamed Mohamed Zahran ; Supervised Fatma Abdelfattah Ragab , Helmy Ismail Heiba

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Sally Samir Mohamed Mohamed Zahran , 2015Description: 147 P. : charts , photographs ; 25cmOther title:
  • تحضير بعض مشتقات السلفوناميد الجديدة و المتوقع لها نشاطا كمضادات للسرطان و كمحفزات لتأثير الإشعاع [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutical Chemistry Summary: In a search for new cytotoxic agents with improved activity and selectivity, certain new sulfonamide derivatives were synthesized. All the newly synthesized compounds were subjected to in vitro cytotoxic screening against human hepatocellular liver carcinoma cell line (HEPG2). The most potent compounds, as concluded from this screening, were selected to be evaluated again for their in vitro cytotoxic activity in combination with Þ-radiation. The new compounds were docked inside the active site of histone deacetylase enzyme in an attempt to predict their mechanism of action
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.05.M.Sc.2015.Sa.S (Browse shelf(Opens below)) Not for loan 01010110067393000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.05.M.Sc.2015.Sa.S (Browse shelf(Opens below)) 67393.CD Not for loan 01020110067393000

Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutical Chemistry

In a search for new cytotoxic agents with improved activity and selectivity, certain new sulfonamide derivatives were synthesized. All the newly synthesized compounds were subjected to in vitro cytotoxic screening against human hepatocellular liver carcinoma cell line (HEPG2). The most potent compounds, as concluded from this screening, were selected to be evaluated again for their in vitro cytotoxic activity in combination with Þ-radiation. The new compounds were docked inside the active site of histone deacetylase enzyme in an attempt to predict their mechanism of action

Issued also as CD

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