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Prognostic significance of 1973 and 2004 WHO classifications of bladder cancer in non - muscle invasive (Ta and T₁) urothelial tumors : A comparative histopathological and immunohistochemical study / Eman Naguib Elhelaly Khorshed Abdelaziz ; Supervised Mohamed Akram Nouh , Iman Gouda Farahat , Hebat Allah Mohammed Shaaban

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Eman Naguib Elhelaly Khorshed Abdelaziz , 2015Description: 179 P. : charts , photographs ; 25cmOther title:
  • الأهمية التنبؤية لكل من نظام لمنظمة الصحة العالمية لتصنيف سرطان المثانة البولية الظهارى الغير غازى للعضلات - ت أ و ت1 : دراسة مقارنة هيستوباثولوجية و كيميائية هيستولوجية مناعية [Added title page title]
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Dissertation note: Thesis (Ph.D.) - Cairo University - National Cancer Institute - Department of Oncology Pathology Summary: From this study, we concluded that: Both WHO grading systems have prognostic significance. Although the new WHO 2004 grading system is more superior over the old 1973 WHO grading system as being significantly correlated with more prognostic factors including patients{u2019} age, presence of bilharziasis, presence of CIS, tumor size, tumor stage, T1 tumors sub-stage, and immunohistochemical expression of well-established prognostic markers (Ki-67 labelling index, p21 and MCM2 expressions). Both the 1973 WHO and the 2004 WHO classifications are effective in predicting tumor progression in NMIBC, but not in predicting tumor recurrence. SUb - staging of T1 tumors according to the level of invasion to the lamina propria and muscularis mucosa is an independent prognostic factor that correlated very well with both WHO grading systems and also proved to be a good predictor for tumor progression. Ki - 67 labelling index is a good predictor for tumor progression. P21 and MCM2 are good predictors for tumor recurrence
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.19.04.Ph.D.2015.Em.P (Browse shelf(Opens below)) Not for loan 01010110067628000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.19.04.Ph.D.2015.Em.P (Browse shelf(Opens below)) 67682.CD Not for loan 01020110067628000

Thesis (Ph.D.) - Cairo University - National Cancer Institute - Department of Oncology Pathology

From this study, we concluded that: Both WHO grading systems have prognostic significance. Although the new WHO 2004 grading system is more superior over the old 1973 WHO grading system as being significantly correlated with more prognostic factors including patients{u2019} age, presence of bilharziasis, presence of CIS, tumor size, tumor stage, T1 tumors sub-stage, and immunohistochemical expression of well-established prognostic markers (Ki-67 labelling index, p21 and MCM2 expressions). Both the 1973 WHO and the 2004 WHO classifications are effective in predicting tumor progression in NMIBC, but not in predicting tumor recurrence. SUb - staging of T1 tumors according to the level of invasion to the lamina propria and muscularis mucosa is an independent prognostic factor that correlated very well with both WHO grading systems and also proved to be a good predictor for tumor progression. Ki - 67 labelling index is a good predictor for tumor progression. P21 and MCM2 are good predictors for tumor recurrence

Issued also as CD

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