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Variation of natural killer cells phenotype and activity in various stages of hepatitis C virus infection in Egyptian patients / Asmaa Elsayed Mohamed Ali ; Supervised Somaya O. Eldeeb , Hosni Salama , Hanan A. Marzouk

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Asmaa Elsayed Mohamed Ali , 2015Description: 154 P. : charts , facsimiles ; 25cmOther title:
  • اختلاف النمط الظاهرى ونشاط الخلايا الطبيعية القاتلة لمراحل الاصابة المختلفة بالالتهاب الكبدى الفيروسى سى فى المرضى المصريين [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Science- Department of Zoology Summary: During the early phases of a hepatitis C virus (HCV) infection, natural killer (NK) cells activation appears to be critical to the innate (non- specific) immune responses that have the potential of clearing the infection. Impaired activity of NK cells has been proposed as a mechanism contributing to viral persistence and chronic infection in HCV infection .We aimed to assess the impact of HCV infections on NK cells regarding frequency, and subset distribution. Peripheral blood (PB) NK cells population of individuals were divided into the following groups: normal individuals :20 and 89 patients at different stages of HCV:37 chronic HCV,28 cirrhotic HCV, and 24 with hepatocellular carcinoma (HCC) .The phenotype and frequency of NK cells were characterized by flow cytometry in the different stages in comparison to normal. The potential associations between the frequency of NK cell subsets and alanine aminotransferase (ALT), and aspartate aminotransferase (AST), as indicators of liver function, were analyzed. The correlation between the phenotype of NK subsets and the various stages was assayed. Number of total NK cells was significantly reduced and a striking shift in NK subsets, with a marked decrease in the CD56dim cell fraction compared to CD56bright cells was identified
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Item type Current library Home library Call number Copy number Status Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.12.21.M.Sc.2015.As.V (Browse shelf(Opens below)) Not for loan 01010110067750000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.12.21.M.Sc.2015.As.V (Browse shelf(Opens below)) 67750.CD Not for loan 01020110067750000

Thesis (M.Sc.) - Cairo University - Faculty of Science- Department of Zoology

During the early phases of a hepatitis C virus (HCV) infection, natural killer (NK) cells activation appears to be critical to the innate (non- specific) immune responses that have the potential of clearing the infection. Impaired activity of NK cells has been proposed as a mechanism contributing to viral persistence and chronic infection in HCV infection .We aimed to assess the impact of HCV infections on NK cells regarding frequency, and subset distribution. Peripheral blood (PB) NK cells population of individuals were divided into the following groups: normal individuals :20 and 89 patients at different stages of HCV:37 chronic HCV,28 cirrhotic HCV, and 24 with hepatocellular carcinoma (HCC) .The phenotype and frequency of NK cells were characterized by flow cytometry in the different stages in comparison to normal. The potential associations between the frequency of NK cell subsets and alanine aminotransferase (ALT), and aspartate aminotransferase (AST), as indicators of liver function, were analyzed. The correlation between the phenotype of NK subsets and the various stages was assayed. Number of total NK cells was significantly reduced and a striking shift in NK subsets, with a marked decrease in the CD56dim cell fraction compared to CD56bright cells was identified

Issued also as CD

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