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Drug Interactions between some antiepileptic and certain hypocholesterolaemic drugs in irradiated animals / Dina Mahmoud Lotfy Shaaban ; Supervised Mostafa E. Elsayed , Seham H.M. Hassan

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Dina Mahmoud Lotfy Shaaban , 2015Description: 213 P. : charts , facsimiles ; 25cmOther title:
  • التداخلات الدوائية بين بعض الأدوية المضادة للصرع وأدوية محددة خافضة للكوليستيرول في الحيوانات المشععة [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology Summary: Drug Interactions between antiepileptic drug such as phenytoin and certain hypocholesterolaemic drug namely rosuvastatin were investigated on several biological parameters. Phenytoin (60mg/kg i.p) and rosuvastatin (1.25 mg/kg i.p) were given either alone and in combination to normal and irradiated animals to investigate drug interactions between the test drugs. Anticonvulsant activity was evaluated using pentylenetetrazole in a dose (80mg/kg i.p) in normal and irradiated mice.Brain neurotransmitters (glutamate and GABA) were investigated. Lipid profile (total cholesterol (TC), Triacylglycerol (TG), High density lipoprotein-cholesterol (HDL-C) and low density lipoprotein- cholesterol (LDL-C) were determined. Liver functions such as serum Aspartate amino transferase (AST) and serum alanine amino transferase (ALT) were also estimated
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.09.M.Sc.2015.Di.D (Browse shelf(Opens below)) Not for loan 01010110067774000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.09.M.Sc.2015.Di.D (Browse shelf(Opens below)) 67774.CD Not for loan 01020110067774000

Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology

Drug Interactions between antiepileptic drug such as phenytoin and certain hypocholesterolaemic drug namely rosuvastatin were investigated on several biological parameters. Phenytoin (60mg/kg i.p) and rosuvastatin (1.25 mg/kg i.p) were given either alone and in combination to normal and irradiated animals to investigate drug interactions between the test drugs. Anticonvulsant activity was evaluated using pentylenetetrazole in a dose (80mg/kg i.p) in normal and irradiated mice.Brain neurotransmitters (glutamate and GABA) were investigated. Lipid profile (total cholesterol (TC), Triacylglycerol (TG), High density lipoprotein-cholesterol (HDL-C) and low density lipoprotein- cholesterol (LDL-C) were determined. Liver functions such as serum Aspartate amino transferase (AST) and serum alanine amino transferase (ALT) were also estimated

Issued also as CD

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