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Toxoplasmosis and abortion : Inflammatory cytokines gene expression of the host immune system / Mona Said Elsherbini ; Supervised Amany Ahmed Abdelaal , Walid Sayed Elsherbiny , Samar Sayed Attia

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Mona Said Elsherbini , 2015Description: 191 P. : charts , facsimiles ; 25cmOther title:
  • داء المقوسات و حالات الإجهاض : التعبير الجيني لسيتوكينات الإلتهاب للجهاز المناعى [Added title page title]
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  • Issued also as CD
Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Parasitology Summary: The main aim of this work was to study gene expression of some important inflammatory cytokines in cases infected with Toxoplasma and presenting with repeated abortion in comparison to Toxoplasma multiparous women as a control. The work comprised a total of 61 serologically Toxoplasma positive women which were divided into; Group1: 19 cases suffering from repeated abortion and failed to complete all pregnancies. Group2: 28 multiparous women. Group3: 14 cases were multiparous and suffering from repeated abortion. For gene expression assay, a quantitative real-time PCR system was optimized using 2 pro-inflammatory cytokines (IFN-Þ & TNF-Ü) and 2 anti-inflammatory cytokines (IL-10 & TGF-Ý). In general, all the studied cytokines were significantly upregulated in Gp1 with a remarkable bias towards the pro-inflammatory cytokines represented by the IFN-Þ particularly, denoting a predominantly inflammatory state in Gp1. In Gp2, the 4 cytokines were approximately in a balanced state with a little shift towards the 2 anti-inflammatory cytokines (IL-10 and TGF-Ý). Besides, a significant positive correlation was reported, indicating a harmony in their expression. In Gp 3, the anti-inflammatory (IL-10) was upregulated; also its negative correlation with the pro-inflammatory cytokine (IFN-Þ), denotes the possible role of this regulatory cytokine in saving pregnancies{u2019} outcomes in Gp3. Hence, the present study hypothesized a potential role of these cytokines in the upcoming prognostic or/and therapeutic concerns
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.26.Ph.D.2015.Mo.T (Browse shelf(Opens below)) Not for loan 01010110067588000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.26.Ph.D.2015.Mo.T (Browse shelf(Opens below)) 67588.CD Not for loan 01020110067588000

Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Parasitology

The main aim of this work was to study gene expression of some important inflammatory cytokines in cases infected with Toxoplasma and presenting with repeated abortion in comparison to Toxoplasma multiparous women as a control. The work comprised a total of 61 serologically Toxoplasma positive women which were divided into; Group1: 19 cases suffering from repeated abortion and failed to complete all pregnancies. Group2: 28 multiparous women. Group3: 14 cases were multiparous and suffering from repeated abortion. For gene expression assay, a quantitative real-time PCR system was optimized using 2 pro-inflammatory cytokines (IFN-Þ & TNF-Ü) and 2 anti-inflammatory cytokines (IL-10 & TGF-Ý). In general, all the studied cytokines were significantly upregulated in Gp1 with a remarkable bias towards the pro-inflammatory cytokines represented by the IFN-Þ particularly, denoting a predominantly inflammatory state in Gp1. In Gp2, the 4 cytokines were approximately in a balanced state with a little shift towards the 2 anti-inflammatory cytokines (IL-10 and TGF-Ý). Besides, a significant positive correlation was reported, indicating a harmony in their expression. In Gp 3, the anti-inflammatory (IL-10) was upregulated; also its negative correlation with the pro-inflammatory cytokine (IFN-Þ), denotes the possible role of this regulatory cytokine in saving pregnancies{u2019} outcomes in Gp3. Hence, the present study hypothesized a potential role of these cytokines in the upcoming prognostic or/and therapeutic concerns

Issued also as CD

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