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Prognostic value of adrenomedullin in patients with left ventricular systolic dysfunction after an acute myocardial infarction / Ahmed Yassin Mohammed ; Supervised M. Sherif Mokhtar , Ahmed Battah , Amal Rizk

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Ahmed Yassin Mohammed , 2015Description: 58 P. : charts ; 25cmOther title:
  • الدلالة التنبؤية لهرمون الأدرينوميداللين لحدوث مضاعفات فى مرضى الضعف الانقباضى فى البطين الأيسر فيما بعد الأحتشاء القلبى الحاد [Added title page title]
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Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Critical Care Medicine Summary: This study sought to assess the prognostic impact of adrenomedullin ADM after an acute myocardial infarction (AMI). Background Adrenomedullin (ADM) is elevated in heart failure (HF) and after AMI and compared it with N-terminal pro-B-type natriuretic peptide (NTproBNP), a marker of death and HF. Methods We measured plasma ADM and NTproBNP in 60 consecutive post-ST elevated AMI patients with systolic dysfunction (< EF 50%), (45 men,represents 75% with mean age57.6±8.4 years old ), 3 to 5 days after chest pain onset. Results Mean age of studied patients was 57.6±8.4 years old (Range 35-80). Males constituted 73.3% of our study population (44 males), , we found mean NYHA 2.8 , mean Killip class of 2.9 and mean TIMI risk score of 8.3. Follow-up was done at 90 days. Forty eight patients survived (80%). Two patients experienced cerebrovascular events (3.3%),two patients experienced re-infarction (3.3%), and seven patients experienced life-threatening arrhythmias (11.7%). ADM had proved to have a significant prognostic value in predicting mortality if compared to Pro-BNP as evidenced by plotting the ROC curve that revealed AUC for ADM to be 0.977 and 0.775 for Pro-BNP . The same significant higher prognostic power for ADM applies for predicting MACE using ROC curve and estimating AUC. Multivariate analysis showed that ADM was the only predictor for MACE. ADM: (OR 1.62, CI 95%: 1.19-2.20, P value .002).
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.09.Ph.D.2015.Ah.P (Browse shelf(Opens below)) Not for loan 01010110067895000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.09.Ph.D.2015.Ah.P (Browse shelf(Opens below)) 67895.CD Not for loan 01020110067895000
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Cai01.11.09.Ph.D.2014.Ta.A Application of dobutamine stress tissue doppler echocardiography for detection of myocardial ischemia in comparison to coronary angiography / Cai01.11.09.Ph.D.2014.Wa.R Role of cardiac MRI and phase analysis gated SPECT in evaluation of left ventricular dys - synchrony and scar burden in determining the outcome of cardiac resynchronization therapy / Cai01.11.09.Ph.D.2014.Wa.R Role of cardiac MRI and phase analysis gated SPECT in evaluation of left ventricular dys - synchrony and scar burden in determining the outcome of cardiac resynchronization therapy / Cai01.11.09.Ph.D.2015.Ah.P Prognostic value of adrenomedullin in patients with left ventricular systolic dysfunction after an acute myocardial infarction / Cai01.11.09.Ph.D.2015.Ah.P Prognostic value of adrenomedullin in patients with left ventricular systolic dysfunction after an acute myocardial infarction / Cai01.11.09.Ph.D.2015.Az.C Comparison between L- FABP and renal artery duplex before and after percutaneous coronary intervention for early detection of acute kidney injury / Cai01.11.09.Ph.D.2015.Az.C Comparison between L- FABP and renal artery duplex before and after percutaneous coronary intervention for early detection of acute kidney injury /

Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Critical Care Medicine

This study sought to assess the prognostic impact of adrenomedullin ADM after an acute myocardial infarction (AMI). Background Adrenomedullin (ADM) is elevated in heart failure (HF) and after AMI and compared it with N-terminal pro-B-type natriuretic peptide (NTproBNP), a marker of death and HF. Methods We measured plasma ADM and NTproBNP in 60 consecutive post-ST elevated AMI patients with systolic dysfunction (< EF 50%), (45 men,represents 75% with mean age57.6±8.4 years old ), 3 to 5 days after chest pain onset. Results Mean age of studied patients was 57.6±8.4 years old (Range 35-80). Males constituted 73.3% of our study population (44 males), , we found mean NYHA 2.8 , mean Killip class of 2.9 and mean TIMI risk score of 8.3. Follow-up was done at 90 days. Forty eight patients survived (80%). Two patients experienced cerebrovascular events (3.3%),two patients experienced re-infarction (3.3%), and seven patients experienced life-threatening arrhythmias (11.7%). ADM had proved to have a significant prognostic value in predicting mortality if compared to Pro-BNP as evidenced by plotting the ROC curve that revealed AUC for ADM to be 0.977 and 0.775 for Pro-BNP . The same significant higher prognostic power for ADM applies for predicting MACE using ROC curve and estimating AUC. Multivariate analysis showed that ADM was the only predictor for MACE. ADM: (OR 1.62, CI 95%: 1.19-2.20, P value .002).

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