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Genetic polymorphism of microsomal epoxide hydrolase among a group of egyptian acquired aplastic anemia patients / Mariam Abdelmesseh Mekhael ; Supervised Hanan Nour Raslan , Manal Mohamed , Mahmoud Makhlouf , Rania Ismail Magdy

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Mariam Abdelmesseh Mekhael , 2015Description: 135 P. : facsimiles ; 25cmOther title:
  • دراسة التعدد الشكلى لجين {uئإ٨٧}نزيم ا{uئإئ٩}يبوكسيد هيدرولاز الميكروسومي في مجموعة من المرضي المصريين المصابين بفشل النخاع العظمى [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology Summary: Microsomal epoxide hydrolase enzyme is involved in xenobiotics detoxification. It catalyzes the phase I hydrolysis of epoxides and plays a role in the detoxification processes and in the metabolism of endogenous and exogenous compounds. Exposure to various environmental toxins with a reduced ability to metabolize them may lead to acquired aplastic anemia (AAA). Individuals vary in their ability to metabolize several DNA-damaging agents due to polymorphisms of biotransforming enzymes. Two variants of human epoxide hydrolase enzyme with different enzyme activity have been described; exon 3 polymorphism is associated with lower enzyme activity whereas exon 4 polymorphism is associated with higher activity. The present study assessed the genetic polymorphisms of the microsomal epoxide hydrolase enzyme (mEPHX) and detected their impact on the susceptibility, disease severity, and prognosis in Egyptian patients with AAA. The mEPHX 113 Tyr-His and 139 His-Arg genotypes were determined by PCR-RFLP, in 50 patients with AA as well as 50 age and sex matched healthy control subjects
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.07.M.Sc.2015.Ma.G (Browse shelf(Opens below)) Not for loan 01010110067899000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.07.M.Sc.2015.Ma.G (Browse shelf(Opens below)) 67899.CD Not for loan 01020110067899000

Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology

Microsomal epoxide hydrolase enzyme is involved in xenobiotics detoxification. It catalyzes the phase I hydrolysis of epoxides and plays a role in the detoxification processes and in the metabolism of endogenous and exogenous compounds. Exposure to various environmental toxins with a reduced ability to metabolize them may lead to acquired aplastic anemia (AAA). Individuals vary in their ability to metabolize several DNA-damaging agents due to polymorphisms of biotransforming enzymes. Two variants of human epoxide hydrolase enzyme with different enzyme activity have been described; exon 3 polymorphism is associated with lower enzyme activity whereas exon 4 polymorphism is associated with higher activity. The present study assessed the genetic polymorphisms of the microsomal epoxide hydrolase enzyme (mEPHX) and detected their impact on the susceptibility, disease severity, and prognosis in Egyptian patients with AAA. The mEPHX 113 Tyr-His and 139 His-Arg genotypes were determined by PCR-RFLP, in 50 patients with AA as well as 50 age and sex matched healthy control subjects

Issued also as CD

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