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Role of opioid receptors in the exercise pressor reflex in sensory neurons / Bassil Hassan Ibrahim Hassan ; Supervised Fawzia Aboulfetouh , Maged Salah Abdalla , Ahmed Mohamed Mukhtar

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Bassil Hassan Ibrahim Hassan , 2015Description: 102 P. : charts , facsimiles ; 25cmOther title:
  • دور المستقبلات المورفينيه في الرد العصبي للإجهاد الرياضي في الأعصاب الحسيه [Added title page title]
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Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Anaesthesia Summary: The aim of the work is to determine the role of peripheral o-opioid receptor to inhibit the excitability of rat DRG sensory neurons expressing EGFP (whose expression was driven by the Nav1.8 promoter region), following rat femoral artery occlusion for 72 hr which is a model likely similar to the blood flow condition in patient with chronic peripheral vascular disease. Then we aimed to determine the specific PTX-sensitive GÜ subunit that mediates the functional coupling of MOR and Ca²⁺ channels and also Ca²⁺ channels expressed in this identified DRG neurons which may help in better understanding of their role in mediating the EPR. This study may provide initial step for the development of novel drugs that selectively suppress the exaggerated exercise induced sympathetic reflex that exacerbates certain human diseases (e.g. peripheral arterial disease and chronic muscle ischemia) and to relive the exercise induced claudicating pain in peripheral vascular disease patients
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.01.Ph.D.2015.Ba.R (Browse shelf(Opens below)) Not for loan 01010110067973000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.01.Ph.D.2015.Ba.R (Browse shelf(Opens below)) 67973.CD Not for loan 01020110067973000

Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Anaesthesia

The aim of the work is to determine the role of peripheral o-opioid receptor to inhibit the excitability of rat DRG sensory neurons expressing EGFP (whose expression was driven by the Nav1.8 promoter region), following rat femoral artery occlusion for 72 hr which is a model likely similar to the blood flow condition in patient with chronic peripheral vascular disease. Then we aimed to determine the specific PTX-sensitive GÜ subunit that mediates the functional coupling of MOR and Ca²⁺ channels and also Ca²⁺ channels expressed in this identified DRG neurons which may help in better understanding of their role in mediating the EPR. This study may provide initial step for the development of novel drugs that selectively suppress the exaggerated exercise induced sympathetic reflex that exacerbates certain human diseases (e.g. peripheral arterial disease and chronic muscle ischemia) and to relive the exercise induced claudicating pain in peripheral vascular disease patients

Issued also as CD

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