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Design, preparation and pharmaceutical evaluation of solid dosage forms for treatment of erectile dysfunction / Doaa Hussein Mobarak ; Supervised Mahmoud Mohamed Ghourab , Salwa Mohamed Salah Eldin

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Doaa Hussein Mobarak , 2015Description: 273 P. : charts ; 25cmOther title:
  • تصميم وتحضير وتقييم لمستحضرات صيدلية صلبة تستخدم فى علاج ضعف الانتصاب [Added title page title]
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  • Issued also as CD
Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics Summary: Self-emulsifying drug delivery system has been proven to be a successful tool to improve the solubility and therefore bioavailability of lipophilic drugs. Upon dilution with the aqueous fluid and mild agitation the self- emulsifying components readily and quickly disperse into microemulsion. Tadalafil is a phosphodiesterase type 5 inhibitor, with an elimination half- life (T1/2) 17.5 hours and 2 hours for the onset of action. Tadalafil is a class II drug, with low solubility, thus having a bioavailability of approximated 30%. Overcoming the delayed onset of action as well as increasing the bioavailability was approached in this study
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.08.Ph.D.2015.Do.D (Browse shelf(Opens below)) Not for loan 01010110068014000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.08.Ph.D.2015.Do.D (Browse shelf(Opens below)) 68014.CD Not for loan 01020110068014000

Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics

Self-emulsifying drug delivery system has been proven to be a successful tool to improve the solubility and therefore bioavailability of lipophilic drugs. Upon dilution with the aqueous fluid and mild agitation the self- emulsifying components readily and quickly disperse into microemulsion. Tadalafil is a phosphodiesterase type 5 inhibitor, with an elimination half- life (T1/2) 17.5 hours and 2 hours for the onset of action. Tadalafil is a class II drug, with low solubility, thus having a bioavailability of approximated 30%. Overcoming the delayed onset of action as well as increasing the bioavailability was approached in this study

Issued also as CD

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