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Developed and validated analytical methods for the determination of some antibacterial drugs / Asmaa Abdelkerim Mandour ; Supervised Ramzia Ismail Elbagary , Khairia Mohamed Ahmed , Asmaa Ahmed Elzaher

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Asmaa Abdelkerim Mandour , 2015Description: 233 P. : charts , facsimiles ; 25cmOther title:
  • طرق تحليلية متطورة ومقيمة لتعين بعض الادوية المضادة للبكتريا [Added title page title]
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Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutical Chemistry Summary: Different methods for the determination of some antibacterial drugs, in bulk, dosage forms and in human plasma have been introduced in this thesis. These drugs are ciprofloxacin hydrochloride, norfloxacin, metronidazole and tinidazole. Chromatographic part includes HPLC determination of some mixtures namely a binary mixture of ciprofloxacin and metronidazole in absence or in presence of acid degradation product of ciprofloxacin and a tertiary mixture of norfloxacin, metronidazole and tinidazole. An UHPLC determination of the tertiary mixture and a stability indication determination of norfloxacin in presence of its acid induced degradation product was applied together with a simultaneous determination of ciprofloxacin in presence of its acid induced degradation product with monolithic column. In addition to a determination of ciprofloxacin in presence of one of its metabolites after being synthesized, in spiked human plasma using UHPLC was proposed. Also, the chromatographic part includes UHPLC-MS/MS simultaneous determination of ciprofloxacin and metronidazole in spiked human plasma
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.05.Ph.D.2015.As.D (Browse shelf(Opens below)) Not for loan 01010110068017000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.05.Ph.D.2015.As.D (Browse shelf(Opens below)) 68017.CD Not for loan 01020110068017000

Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutical Chemistry

Different methods for the determination of some antibacterial drugs, in bulk, dosage forms and in human plasma have been introduced in this thesis. These drugs are ciprofloxacin hydrochloride, norfloxacin, metronidazole and tinidazole. Chromatographic part includes HPLC determination of some mixtures namely a binary mixture of ciprofloxacin and metronidazole in absence or in presence of acid degradation product of ciprofloxacin and a tertiary mixture of norfloxacin, metronidazole and tinidazole. An UHPLC determination of the tertiary mixture and a stability indication determination of norfloxacin in presence of its acid induced degradation product was applied together with a simultaneous determination of ciprofloxacin in presence of its acid induced degradation product with monolithic column. In addition to a determination of ciprofloxacin in presence of one of its metabolites after being synthesized, in spiked human plasma using UHPLC was proposed. Also, the chromatographic part includes UHPLC-MS/MS simultaneous determination of ciprofloxacin and metronidazole in spiked human plasma

Issued also as CD

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