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Potential neuroprotective effect of gangliosides in global cerebral ischemia-reperfusion in rats / Ali Mohamed Ali Mohamed Abdellatif Choucry ; Supervised Hanan Salah Eldin Elabhar , Ahmed Sherif Mohamed Attia , Muhammad Yusuf Alshorbagy

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Ali Mohamed Ali Mohamed Abdellatif Choucry , 2015Description: 191 P. : charts , facsimiles ; 25cmOther title:
  • احتمالية التأثير الوقائي للجانجليوسايدز على الأعصاب في نموذج نقص الدم العام و اعادة التروية في الجرذان [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology Summary: This study aimed to explore if the monosialoganglioside GM1 could mediate neuroprotection in global ischemia/reperfusion (I/R) insult and to investigate the role of tropomyosin related kinase (Trk) receptor, p75 neurotrophin receptor (p75NTR), and the pro and mature forms of nerve growth factor (NGF) in mediating GM1 effects. This study also tested if GM1 effects could be modulated by concurrent administration of the flavanol Epicatechin (EPI). Global ischemia was mediated by occluding both carotid arteries for 30 min., which was followed by a one week reperfusion period. Measured effectors of Trk and p75NTR increased with the used treatments, and the burst of pro/mature NGF ratio that was observed a week after I/R was effectively reduced by all treatment regimens. This was associated with an improvement in both memory retention and acquisition functions, as observed by the Morris water maze test
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.09.M.Sc.2015.Al.P (Browse shelf(Opens below)) Not for loan 01010110068077000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.09.M.Sc.2015.Al.P (Browse shelf(Opens below)) 68077.CD Not for loan 01020110068077000

Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology

This study aimed to explore if the monosialoganglioside GM1 could mediate neuroprotection in global ischemia/reperfusion (I/R) insult and to investigate the role of tropomyosin related kinase (Trk) receptor, p75 neurotrophin receptor (p75NTR), and the pro and mature forms of nerve growth factor (NGF) in mediating GM1 effects. This study also tested if GM1 effects could be modulated by concurrent administration of the flavanol Epicatechin (EPI). Global ischemia was mediated by occluding both carotid arteries for 30 min., which was followed by a one week reperfusion period. Measured effectors of Trk and p75NTR increased with the used treatments, and the burst of pro/mature NGF ratio that was observed a week after I/R was effectively reduced by all treatment regimens. This was associated with an improvement in both memory retention and acquisition functions, as observed by the Morris water maze test

Issued also as CD

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