Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Critical Care Medicine

C- reactive protein (CRP) value can identify the risk level for acute coronary syndrome (ACS). Ivabradine, a selective inhibitor of the funny current channel, reduces resting and exercise HR without affecting cardiac contractility or blood pressure. Evaluate the influence of Ivabradine on long term prevention of major adverse cardiac events (MACE) using high sensitivity crp (hs CRP ). 60 pts admitted with ACS over the period of 6 months. Cardiac enzymes were withdrawn on admision and every 6 hours thereafter for 24 hours then followed up daily for five days and when indicated. high sensitivity C- reactive protein (hs - CRP) (quantitative value) which was done on day of admission and repeated for follow up at day 4 and at day 30 patients diveded into two groups each 30 pts: group (A) who received conventional therapy and ivabradine, group ( B ) who recieved conventional therapy only. Ivabradine given within 48hr of admission 5 mg twice daily upgraded to 7,5 mg twice daily after one week if tolerable myocardial perfusion imaging (MPI):Patients were subjected to technetium99 sesta MIBI myocardial perfusion imaging (MPI) within 6 to 8 hours after admission and were followed up on day 30 with the same dose of injection using multi - sepct siemens dual head gamma camera

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