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A histological study on the protective effect of endogenous stem cells mobilization in adriamycin-induced chronic nephropathy in rats / Asmaa Ahmed Elshafei ; Supervised Eman Mostafa Sadek , Nagla Mohamed Salama , Dalia Ibrahim Ismail

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Asmaa Ahmed Elshafei , 2015Description: 132 P. : facsimiles ; 25cmOther title:
  • دراسة هستولوجية للتأثير الوقائى لتحريك الخلايا الجذعية الداخلية فى الإعتلال الكلوي المزمن المحدث بعقار الأدرياميسين في الجرذان [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Histology Summary: Chronic kidney disease (CKD) is a global public health problem with increasing morbidity and mortality. Therefore, this study was planned to test the protective effect of hematopoietic stem cells mobilization by granulocyte-colony stimulating factor (G-CSF) on adriamycin (ADR)-induced chronic renal diseasein rats. Thirty albino rats were classified into three groups: control, ADR group: rats received single intravenous injection of ADR(5mg/kg) and G-CSF group: rats received ADR by the same route and the same dose asthe previous group then G-CSF (70æg/kg/day) two hours after ADR injectionthen daily for 5 consecutive days. At time of sacrifice (after 6 weeks), blood samples were taken toestimate blood urea nitrogen (BUN) &serum creatinine. Kidneys sections were stained with H&E, Masson{u2019}s trichrome, PAS stains&Immunohistochemichal staining against CD34 & caspase-3. G-CSF treated group exhibited protection against renal injury manifested by reducing blood urea nitrogenand serum creatinine levels,improving histological architecture and increasing theproliferative capacity of renal tubule
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.16.M.Sc.2015.As.H (Browse shelf(Opens below)) Not for loan 01010110068144000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.16.M.Sc.2015.As.H (Browse shelf(Opens below)) 68144.CD Not for loan 01020110068144000
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Cai01.11.16.M.Sc.2015.As.E The effect of garlic extract on induced wound in non diabetic and diabetic male rat : Possible role of endogenous stem cells / Cai01.11.16.M.Sc.2015.As.E The effect of garlic extract on induced wound in non diabetic and diabetic male rat : Possible role of endogenous stem cells / Cai01.11.16.M.Sc.2015.As.H A histological study on the protective effect of endogenous stem cells mobilization in adriamycin-induced chronic nephropathy in rats / Cai01.11.16.M.Sc.2015.As.H A histological study on the protective effect of endogenous stem cells mobilization in adriamycin-induced chronic nephropathy in rats / Cai01.11.16.M.Sc.2015.Di.R Role of adipose-derived stem cells in restoring ovarian structure of adult albino rats with chemotherapy-induced ovarian failure : A histological and immunohistochemical study / Cai01.11.16.M.Sc.2015.Di.R Role of adipose-derived stem cells in restoring ovarian structure of adult albino rats with chemotherapy-induced ovarian failure : A histological and immunohistochemical study / Cai01.11.16.M.Sc.2015.Ro.R Role of erythropoietin induced mobilization of hematopoietic stem cells in kidney repair following ischemia reperfusion injury in albino Rats : Histological and immunohistochemical study /

Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Histology

Chronic kidney disease (CKD) is a global public health problem with increasing morbidity and mortality. Therefore, this study was planned to test the protective effect of hematopoietic stem cells mobilization by granulocyte-colony stimulating factor (G-CSF) on adriamycin (ADR)-induced chronic renal diseasein rats. Thirty albino rats were classified into three groups: control, ADR group: rats received single intravenous injection of ADR(5mg/kg) and G-CSF group: rats received ADR by the same route and the same dose asthe previous group then G-CSF (70æg/kg/day) two hours after ADR injectionthen daily for 5 consecutive days. At time of sacrifice (after 6 weeks), blood samples were taken toestimate blood urea nitrogen (BUN) &serum creatinine. Kidneys sections were stained with H&E, Masson{u2019}s trichrome, PAS stains&Immunohistochemichal staining against CD34 & caspase-3. G-CSF treated group exhibited protection against renal injury manifested by reducing blood urea nitrogenand serum creatinine levels,improving histological architecture and increasing theproliferative capacity of renal tubule

Issued also as CD

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