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Assessment of serum soluble CD163 (sCD163) As A non-Invasive tool for diagnosis and prognosis of gastro-oesophageal varices In patients with liver cirrhosis / Amal Anwar Helmy ; Supervised Rabab Fouad Emam , Iman Mohammed Hamza , Marwa Khairy Mehasseb

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Amal Anwar Helmy , 2015Description: 147 P. : charts , facsimiles ; 25cmOther title:
  • كاداة تشخيصية وتنبؤية بمسار دوالى المعدة والمرئ فى مرضى التشمع الكبدى (sCD163)القابل للذوبان فى المصل (CD163) تقييم [Added title page title]
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Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Tropical Medicine Summary: Background and aim: Research is continuous for imaging and laboratory tools that are more suitable for prediction of portal hypertension than upper GI endoscopy. Serum sCD163 correlates with HVPG and is a possible good indicator of portal hypertension. We investigated sCD163 as a non-invasive tool of predicting the presence and size of oesophageal varices against upper GI endoscopy as the gold standard as well as a stratification tool to identify patients who benefit from individualized surveillance or secondary prophylaxis. Results: sCD163 levels were higher in patients having large varices (p = 0.012), at risk of bleeding (p = 0.04) and the bleeding patients (p = 0.001). Higher portal vein and splenic diameters, APRI, FIB4, Lok{u2019}s score, Fibroindex and AAR but lower albumin levels, platelets count and platelet/spleen ratio, were significantly in patients with varices. Plt/spleen ratio had the best performance model in predicting varices using multivariate analysis with correct classification of 75.9%. Conclusion: Higher sCD163 levels were associated with large varices, risk of bleeding, and variceal bleeding. Platelet/spleen ratios performed better in predicting varices than sCD163
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.33.Ph.D.2015.Am.A (Browse shelf(Opens below)) Not for loan 01010110068312000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.33.Ph.D.2015.Am.A (Browse shelf(Opens below)) 68312.CD Not for loan 01020110068312000

Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Tropical Medicine

Background and aim: Research is continuous for imaging and laboratory tools that are more suitable for prediction of portal hypertension than upper GI endoscopy. Serum sCD163 correlates with HVPG and is a possible good indicator of portal hypertension. We investigated sCD163 as a non-invasive tool of predicting the presence and size of oesophageal varices against upper GI endoscopy as the gold standard as well as a stratification tool to identify patients who benefit from individualized surveillance or secondary prophylaxis. Results: sCD163 levels were higher in patients having large varices (p = 0.012), at risk of bleeding (p = 0.04) and the bleeding patients (p = 0.001). Higher portal vein and splenic diameters, APRI, FIB4, Lok{u2019}s score, Fibroindex and AAR but lower albumin levels, platelets count and platelet/spleen ratio, were significantly in patients with varices. Plt/spleen ratio had the best performance model in predicting varices using multivariate analysis with correct classification of 75.9%. Conclusion: Higher sCD163 levels were associated with large varices, risk of bleeding, and variceal bleeding. Platelet/spleen ratios performed better in predicting varices than sCD163

Issued also as CD

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