Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology

Background: Multiple organ dysfunction syndrome (MODS) is a systemic, dysfunctional inflammatory response characterized with high mortality rate. The Interleukin-17 (IL-17) family is generally regarded as a bridge system connecting innate and adaptive immunity in induction and mediation of pro-inflammatory responses. Aim of work: The aim of the present study is to investigate association between IL- 17 and MODS in polytrauma patients as well as to test the clinical relevance of IL-17 single nucleotide polymorphism (rs1974226) in patients with major trauma. Results: IL-17 serum level was significantly increased (p=0.039) in group I versus group II patients. As for the IL-17 genotyping, the present study revealed no association (p=0.197) between IL-17 rs1974226 different genotypes and the development of MODS. With regards to mortality, IL-17 serum level was significantly higher (p =0.016) in patients who had a lethal outcome versus those who survived. The ROC curve analysis showed that IL-17 can be a promising biomarker in the prediction of MODS (AUC=0.721) in patients with polytrauma. Conclusion: IL-17 can be considered an important early biochemical marker for predicting the development of MODS. On the other hand, IL-17 rs1974226 might not be associated with the occurrence of MODS

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