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Gene polymorphism of MxA in patients with chronic hepatitis C / Sameh Ramadan Abdelfatah ; Supervised Maissa Elraziky , Olfat Shaker , Rabab Salama

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Sameh Ramadan Abdelfatah , 2015Description: 107 P. : charts ; 25cmOther title:
  • الالتهاب الكبدي لفيروس ((سي)) المزمن M.X.Aالتعدد الجيني لجين [Added title page title]
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  • Issued also as CD
Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Tropical Medicine Summary: Hepatitis C virus (HCV) is a major public health problem and is considered the most common etiology of chronic liver disease in Egypt. Many studies were conducted to find accurate prediction of response prior to initiation of therapy. Aim of work: To prove serum MxA 88, 123 polymorphism if can be used as a predictor of response to treatment of chronic HCV Egyptian patients. Patients and methods: The study was conducted on 94 patients with chronic HCV who received pegylated interferon & ribavirin. And 20 healthy subjectsall patients were subjected to pretreatment routine laboratory evaluation and pretreatment serum MxA88, 123polymorphism. Results:the presence of MxA88GGor MxA123CC is a significant for the non-response and there was statistical significant association between response for treatment and albumin, AST, ALT, AFP, bilirubin, Platelets Conclusion: Pretreatment serum MxA 88, 123 polymorphismcan be used as a predictor of response to combination therapy in chronic HCV Egyptian patients
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.33.Ph.D.2015.Sa.G (Browse shelf(Opens below)) Not for loan 01010110068436000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.33.Ph.D.2015.Sa.G (Browse shelf(Opens below)) 68436.CD Not for loan 01020110068436000

Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Tropical Medicine

Hepatitis C virus (HCV) is a major public health problem and is considered the most common etiology of chronic liver disease in Egypt. Many studies were conducted to find accurate prediction of response prior to initiation of therapy. Aim of work: To prove serum MxA 88, 123 polymorphism if can be used as a predictor of response to treatment of chronic HCV Egyptian patients. Patients and methods: The study was conducted on 94 patients with chronic HCV who received pegylated interferon & ribavirin. And 20 healthy subjectsall patients were subjected to pretreatment routine laboratory evaluation and pretreatment serum MxA88, 123polymorphism. Results:the presence of MxA88GGor MxA123CC is a significant for the non-response and there was statistical significant association between response for treatment and albumin, AST, ALT, AFP, bilirubin, Platelets Conclusion: Pretreatment serum MxA 88, 123 polymorphismcan be used as a predictor of response to combination therapy in chronic HCV Egyptian patients

Issued also as CD

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