header
Image from OpenLibrary

The possible protective effect of turmeric extract on the metabolic dysfunction induced by some anticancer drugs in rat liver / Inas Mohamed Ahmed Mahmoud ; Supervised Amira A. Shaheen , Zakaria A. Teleb , Shohda A. Elmaraghy

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Inas Mohamed Ahmed Mahmoud , 2015Description: 146 P. : charts ; 25cmOther title:
  • التأثيرالوقائي المحتمل لمستخلص الكركم علي الخلل الأيضي في كبد الجرذان المحدث ببعض أدوية علاج السرطان [Added title page title]
Subject(s): Available additional physical forms:
  • Issued also as CD
Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Biochemistry Summary: The present study was designed to determine the protective effects of turmeric extract against oxidative damage caused by either cisplatin or paclitaxel in liver, by measuring biochemical and antioxidant parameters and investigating DNA fragmentation and histopathology of liver tissues. It was also directed to evaluate the inhibitory effects of cisplatin and paclitaxel on two CYP450 enzymes namely CYP2E1 and CYP3A1/2 in hepatic microsomes isolated from normal and turmeric pretreated rats. For in-vivo study: male Wistar rats were divided into six groups 10 rats each, cisplatin group (7.5mg/ kg body weight, once i.p.), turmeric extract+ cisplatin group, (100mg/kg b. wt. of turmeric extract for15 days followed by a single injection of cisplatin on day 11); paclitaxel group (10mg/ kg b. wt., once, i.p.), turmeric extract+ paclitaxel group, (100mg/kg b. wt. of turmeric extract for 15 days followed by a single injection of paclitaxel on day 11). For comparison normal saline and Cremophor EL groups were administered in the same dosage regimen. Pretreatment with turmeric extract significantly ameliorated liver damage by reducing the higher activities of serum ALT, AST and LDH, and restored serum proteins and albumin to their normal levels. Furthermore, these treatments improved the state of oxidative stress caused by cisplatin and paclitaxel as indicated by decreasing the level of MDA, elevating the level of GSH, and decreasing the activities of GST, lysosomal enzymes and increasing the activities of SOD. DNA fragmentation caused by both drugs was improved by turmeric extract pretreatment. The biochemical findings were confirmed histopathologically where turmeric pretreatment significantly alleviated the degenerative changes caused by cisplatin and paclitaxel
Tags from this library: No tags from this library for this title. Log in to add tags.
Star ratings
    Average rating: 0.0 (0 votes)
Holdings
Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.01.M.Sc.2015.In.P (Browse shelf(Opens below)) Not for loan 01010110068470000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.01.M.Sc.2015.In.P (Browse shelf(Opens below)) 68470.CD Not for loan 01020110068470000

Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Biochemistry

The present study was designed to determine the protective effects of turmeric extract against oxidative damage caused by either cisplatin or paclitaxel in liver, by measuring biochemical and antioxidant parameters and investigating DNA fragmentation and histopathology of liver tissues. It was also directed to evaluate the inhibitory effects of cisplatin and paclitaxel on two CYP450 enzymes namely CYP2E1 and CYP3A1/2 in hepatic microsomes isolated from normal and turmeric pretreated rats. For in-vivo study: male Wistar rats were divided into six groups 10 rats each, cisplatin group (7.5mg/ kg body weight, once i.p.), turmeric extract+ cisplatin group, (100mg/kg b. wt. of turmeric extract for15 days followed by a single injection of cisplatin on day 11); paclitaxel group (10mg/ kg b. wt., once, i.p.), turmeric extract+ paclitaxel group, (100mg/kg b. wt. of turmeric extract for 15 days followed by a single injection of paclitaxel on day 11). For comparison normal saline and Cremophor EL groups were administered in the same dosage regimen. Pretreatment with turmeric extract significantly ameliorated liver damage by reducing the higher activities of serum ALT, AST and LDH, and restored serum proteins and albumin to their normal levels. Furthermore, these treatments improved the state of oxidative stress caused by cisplatin and paclitaxel as indicated by decreasing the level of MDA, elevating the level of GSH, and decreasing the activities of GST, lysosomal enzymes and increasing the activities of SOD. DNA fragmentation caused by both drugs was improved by turmeric extract pretreatment. The biochemical findings were confirmed histopathologically where turmeric pretreatment significantly alleviated the degenerative changes caused by cisplatin and paclitaxel

Issued also as CD

There are no comments on this title.

to post a comment.