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Phytochemical and biological study of certain Euphorbia species cultivated in Egypt / Shaimaa Rashad Ahmed Morsi ; Supervised Moshera Mohamed Elsherei , Wafaa Tawfik Islam , Riham Salah Eldine

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Shaimaa Rashad Ahmed Morsi , 2015Description: 365 P. : charts ; 25cmOther title:
  • دراسة فيتىوكيميائية و بيىولوجية لبعض انواع ايوفوربيا المنزرعه فى مصر [Added title page title]
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Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmacognosy Summary: The chloroform fraction of the latex and methanolic extract of the aerial parts of Euphorbia cooperi N. E. Br., its chloroform and n-butanol fractions were tested for their cytotoxic activity on breast cancer (MCF7), hepatocellular carcinoma (HepG2), and cervix cancer (HELA) cells. The highest effect of all tested extracts was observed against the breast cancer (MCF7) while the least against the cervix cell line (HELA). Moderate activity against hepatocellular carcinoma (HepG2) was shown by the latex and n-butanol extracts. In vitro antioxidant effect of the methanol extract, chloroform and n-butanol fractions of the aerial parts was determined using DPPH scavenging method. The n-butanol fraction showed the highest antioxidant activity followed by the methanolic extract. The chloroform fraction showed the lowest antioxidant activity. Pretreatment with the methanolic extract and the n-butanol fraction of the aerial parts significantly showed an inhibition in the paracetamol-induced hepatotoxicity while pretreatment with the chloroform fraction of the aerial parts showed no significant effect which confirmed by histopathological studies
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.07.Ph.D.2015.Sh.P (Browse shelf(Opens below)) Not for loan 01010110068476000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.07.Ph.D.2015.Sh.P (Browse shelf(Opens below)) 68476.CD Not for loan 01020110068476000

Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmacognosy

The chloroform fraction of the latex and methanolic extract of the aerial parts of Euphorbia cooperi N. E. Br., its chloroform and n-butanol fractions were tested for their cytotoxic activity on breast cancer (MCF7), hepatocellular carcinoma (HepG2), and cervix cancer (HELA) cells. The highest effect of all tested extracts was observed against the breast cancer (MCF7) while the least against the cervix cell line (HELA). Moderate activity against hepatocellular carcinoma (HepG2) was shown by the latex and n-butanol extracts. In vitro antioxidant effect of the methanol extract, chloroform and n-butanol fractions of the aerial parts was determined using DPPH scavenging method. The n-butanol fraction showed the highest antioxidant activity followed by the methanolic extract. The chloroform fraction showed the lowest antioxidant activity. Pretreatment with the methanolic extract and the n-butanol fraction of the aerial parts significantly showed an inhibition in the paracetamol-induced hepatotoxicity while pretreatment with the chloroform fraction of the aerial parts showed no significant effect which confirmed by histopathological studies

Issued also as CD

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